INT316064

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RBPJ) mitochondrion (Csl) DNA binding (RBPJ)
cytoplasm (RBPJ) nucleolus (RBPJ) nucleus (RBPJ)
Anatomy Link Frequency
nucleus 1
RBPJ (Homo sapiens)
Csl (Mus musculus)
Pain Link Frequency Relevance Heat
interneuron 1 71.12 Quite High
Central nervous system 2 70.72 Quite High
medulla 1 69.80 Quite High
Hippocampus 6 66.96 Quite High
Pyramidal cell 1 66.20 Quite High
Inflammation 43 5.00 Very Low Very Low Very Low
cINOD 36 5.00 Very Low Very Low Very Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 5 86.48 High High
Brain Injury 3 86.00 High High
Disease 81 85.44 High High
Nervous System Malformation 1 70.08 Quite High
Neurodegenerative Disease 5 36.08 Quite Low
INFLAMMATION 60 5.00 Very Low Very Low Very Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Dementia 14 5.00 Very Low Very Low Very Low
Cognitive Disorder 13 5.00 Very Low Very Low Very Low
Amyloid Plaque 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NICD then translocates to the nucleus where binds to CBF1/RBPJk/Su(H)/Lag1 (CSL) family of transcriptional activators or repressors that participate in the transcriptional control of downstream target genes.
RBPJk Binding (binds) of CSL in nucleus
1) Confidence 0.16 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.33 Pain Relevance 0.20

General Comments

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