INT316079

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 6.88
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Vapa) cell death (Vapa) endoplasmic reticulum (Vapa)
structural molecule activity (Vapa) plasma membrane (Vapa) signal transducer activity (Vapa)
Anatomy Link Frequency
head 2
Vapa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
peptic ulcer disease 5 98.68 Very High Very High Very High
anesthesia 10 15.52 Low Low
cva 5 6.44 Low Low
Opioid 160 5.00 Very Low Very Low Very Low
Morphine 155 5.00 Very Low Very Low Very Low
withdrawal 100 5.00 Very Low Very Low Very Low
Versed 85 5.00 Very Low Very Low Very Low
cytokine 55 5.00 Very Low Very Low Very Low
Analgesic 55 5.00 Very Low Very Low Very Low
Clonidine 45 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pneumonia 165 100.00 Very High Very High Very High
Sleep Disorders 375 99.80 Very High Very High Very High
Ulcers 5 98.68 Very High Very High Very High
Disease 20 98.16 Very High Very High Very High
Infection 390 63.60 Quite High
Hypoxia 5 43.96 Quite Low
Apoptosis 25 42.00 Quite Low
Intracranial Hypertension 5 6.44 Low Low
Sepsis 65 5.00 Very Low Very Low Very Low
Critical Illness 45 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several recent studies evaluated the efficacy of an expanded ventilator bundle, including daily interruption of sedation, for the reduction of VAP in ICU patients [130-135].
Negative_regulation (reduction) of VAP associated with pneumonia and sleep disorders
1) Confidence 0.03 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 1.31 Pain Relevance 0.06
In addition, whether this reduction in VAP rate is related to daily interruption of sedation or to other measures used to prevent VAP, such as head-of-bed-elevation, peptic ulcer disease prophylaxis, oral care, or hand washing, is unknown.


Negative_regulation (prevent) of VAP in head associated with peptic ulcer disease, pneumonia, disease and sleep disorders
2) Confidence 0.03 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 1.41 Pain Relevance 0.10
In addition, whether this reduction in VAP rate is related to daily interruption of sedation or to other measures used to prevent VAP, such as head-of-bed-elevation, peptic ulcer disease prophylaxis, oral care, or hand washing, is unknown.


Spec (whether) Negative_regulation (reduction) of VAP in head associated with peptic ulcer disease, pneumonia, disease and sleep disorders
3) Confidence 0.03 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 1.40 Pain Relevance 0.10
However, many of these studies are difficult to interpret because they do not report bundle compliance rate, do not control for other specific VAP risk factors, and use the clinical definition of VAP [136].
Negative_regulation (definition) of VAP associated with pneumonia
4) Confidence 0.03 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 1.42 Pain Relevance 0.09
A significant reduction of VAP rate was found by these studies.
Negative_regulation (reduction) of VAP associated with pneumonia
5) Confidence 0.03 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 1.33 Pain Relevance 0.07

General Comments

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