INT3161

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Context Info
Confidence 0.61
First Reported 1975
Last Reported 2010
Negated 13
Speculated 27
Reported most in Abstract
Documents 163
Total Number 190
Disease Relevance 35.43
Pain Relevance 59.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
pituitary 32
plasma 18
anterior pituitary 14
brain 6
ovary 6
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 345 100.00 Very High Very High Very High
Clonidine 235 100.00 Very High Very High Very High
agonist 194 100.00 Very High Very High Very High
antagonist 177 100.00 Very High Very High Very High
narcan 167 100.00 Very High Very High Very High
Sumatriptan 76 100.00 Very High Very High Very High
Opioid 56 100.00 Very High Very High Very High
opiate 44 100.00 Very High Very High Very High
dexamethasone 21 100.00 Very High Very High Very High
Serotonin 12 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acromegaly 265 100.00 Very High Very High Very High
Obesity 143 100.00 Very High Very High Very High
Polycystic Ovary Syndrome 19 100.00 Very High Very High Very High
Acid Base Imbalance 12 100.00 Very High Very High Very High
Injury 4 100.00 Very High Very High Very High
Diabetes Mellitus 76 99.84 Very High Very High Very High
Headache 23 99.84 Very High Very High Very High
Depression 16 99.84 Very High Very High Very High
Chronic Renal Failure 10 99.84 Very High Very High Very High
Hypertension 8 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sleep, clonidine, and their interactive effect on growth hormone secretion in normal men.
Regulation (effect) of Localization (secretion) of growth hormone associated with clonidine
1) Confidence 0.61 Published 1990 Journal Psychoneuroendocrinology Section Title Doc Link 2195577 Disease Relevance 0 Pain Relevance 0.57
We examined the effect of daytime sleep on GH secretion in normal men taking placebo or clonidine orally, using a two-group blind design (placebo, clonidine; n = 9 each).
Spec (examined) Regulation (effect) of Localization (secretion) of GH associated with clonidine
2) Confidence 0.61 Published 1990 Journal Psychoneuroendocrinology Section Abstract Doc Link 2195577 Disease Relevance 0 Pain Relevance 0.50
Morphine at doses of 5 mg and 10 mg does not stimulate growth hormone (GH) secretion in normal subjects, and its effect on GH secretion in acromegaly is not widely documented.
Regulation (effect) of Localization (secretion) of GH associated with acromegaly and morphine
3) Confidence 0.60 Published 2005 Journal Horm. Metab. Res. Section Abstract Doc Link 16034714 Disease Relevance 0.33 Pain Relevance 0.39
Effect of opiates on growth hormone secretion in acromegaly.
Regulation (Effect) of Localization (secretion) of growth hormone associated with acromegaly and opiate
4) Confidence 0.60 Published 2005 Journal Horm. Metab. Res. Section Title Doc Link 16034714 Disease Relevance 0.42 Pain Relevance 0.61
In order to establish possible alterations in the gamma aminobutyric acid (GABA)ergic control of growth hormone (GH) secretion in heroin addicts, ten patients (age, 25.8 +/- 1.07 yr (mean +/- SE); duration of heroin addiction, range 3-8 yr; weight, 67.3 +/- 0.87 kg body weight), and ten age (29.1 +/- 0.84 yr)- and weight (69.7 +/- 0.87 kg)-matched normal controls were tested with the GABAergic B-receptor agonist baclofen (10 mg p.o. at 09.00 h) (experimental test) or a placebo (control test).
Regulation (control) of Localization (secretion) of growth hormone in body associated with addiction, gaba, body weight, gabaergic, agonist and opiate addiction
5) Confidence 0.60 Published 1992 Journal Life Sci. Section Abstract Doc Link 1625515 Disease Relevance 0.19 Pain Relevance 0.22
These data show that the control of GH secretion mediated by GABAergic B-receptors is impaired in heroin addicts.
Regulation (control) of Localization (secretion) of GH associated with gabaergic
6) Confidence 0.60 Published 1992 Journal Life Sci. Section Abstract Doc Link 1625515 Disease Relevance 0.18 Pain Relevance 0.36
To further investigate the central adrenergic regulation of GH secretion 10 micrograms of noradrenaline or adrenaline was microinjected (1 microliter) directly into the preoptic area of the hypothalamus of ovariectomized ewes.
Spec (investigate) Regulation (regulation) of Localization (secretion) of GH in hypothalamus associated with noradrenaline
7) Confidence 0.58 Published 1994 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 8045100 Disease Relevance 0 Pain Relevance 0.37
In conclusion, these results provide evidence for the involvement of the adrenergic system in the regulation of GH secretion in sheep.
Regulation (involvement) of Localization (secretion) of GH
8) Confidence 0.58 Published 1994 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 8045100 Disease Relevance 0 Pain Relevance 0.38
This study examined the role of the adrenergic system in the regulation of growth hormone (GH) secretion in sheep.
Spec (examined) Regulation (role) of Localization (secretion) of growth hormone
9) Confidence 0.58 Published 1994 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 8045100 Disease Relevance 0 Pain Relevance 0.27
Adrenergic regulation of growth hormone secretion in the ewe.
Regulation (regulation) of Localization (secretion) of growth hormone
10) Confidence 0.58 Published 1994 Journal Domest. Anim. Endocrinol. Section Title Doc Link 8045100 Disease Relevance 0 Pain Relevance 0.33
We evaluated the effect of a low intravenous dose (1 mg/m2) of dexamethasone on GH secretion in 8 short normal children and in 6 GH-deficient children.
Regulation (effect) of Localization (secretion) of GH associated with dexamethasone
11) Confidence 0.57 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9195203 Disease Relevance 0 Pain Relevance 0.32
Effect of low-dose oral and intravenous dexamethasone administration on growth hormone secretion in children.
Regulation (Effect) of Localization (secretion) of growth hormone associated with dexamethasone
12) Confidence 0.57 Published 1997 Journal Horm. Res. Section Title Doc Link 9195203 Disease Relevance 0 Pain Relevance 0.44
Defective 5-HT 1-receptor-mediated neurotransmission in the control of growth hormone secretion in Parkinson's disease.
Regulation (control) of Localization (secretion) of growth hormone associated with disease
13) Confidence 0.57 Published 1997 Journal Neuropsychobiology Section Title Doc Link 9097298 Disease Relevance 0.55 Pain Relevance 0.37
These data show that Parkinson's disease is associated with an impairment in the 5-HT1-receptor-mediated serotonergic transmission in the control of GH secretion, suggesting that this specific defect might alter other serotonergic-mediated mechanisms in the parkinsonian brain.
Regulation (control) of Localization (secretion) of GH in brain associated with parkinson's disease and disease
14) Confidence 0.57 Published 1997 Journal Neuropsychobiology Section Abstract Doc Link 9097298 Disease Relevance 0.64 Pain Relevance 0.35
A significant GH increase was observed in normal controls after sumatriptan injection; in contrast, GH secretion was not modified by sumatriptan administration in parkinsonian patients.
Neg (not) Regulation (modified) of Localization (secretion) of GH associated with parkinson's disease and sumatriptan
15) Confidence 0.57 Published 1997 Journal Neuropsychobiology Section Abstract Doc Link 9097298 Disease Relevance 0.64 Pain Relevance 0.39
Since the alpha adrenergic system plays an important role in hypothalamic regulation of GH secretion, we tested the hypothesis that altered central adrenergic activity contributes to the increased GH concentrations in diabetes.
Regulation (role) of Localization (secretion) of GH associated with diabetes mellitus
16) Confidence 0.54 Published 1985 Journal Pediatr. Res. Section Abstract Doc Link 2989759 Disease Relevance 0.40 Pain Relevance 0.26
Our findings support the contention that metabolic control of diabetes influences hypothalamic regulation of GH secretion and suggests that such alterations are related, at least in part, to changes in central alpha-adrenergic activity.
Regulation (regulation) of Localization (secretion) of GH associated with diabetes mellitus
17) Confidence 0.54 Published 1985 Journal Pediatr. Res. Section Abstract Doc Link 2989759 Disease Relevance 0.37 Pain Relevance 0.26
A significant GH increase was observed in normal controls after sumatriptan or GHB injection; in contrast, GH secretion was not modified by sumatriptan or GHB administration in alcoholic patients.
Neg (not) Regulation (modified) of Localization (secretion) of GH associated with sumatriptan
18) Confidence 0.53 Published 1997 Journal Alcohol Alcohol. Section Abstract Doc Link 9131896 Disease Relevance 0 Pain Relevance 0.56
Persistence of defective serotonergic and GABAergic controls of growth hormone secretion in long-term abstinent alcoholics.
Regulation (controls) of Localization (secretion) of growth hormone associated with gabaergic
19) Confidence 0.53 Published 1997 Journal Alcohol Alcohol. Section Title Doc Link 9131896 Disease Relevance 0 Pain Relevance 0.52
Elevated GH levels at baseline occurred in four out of five female subjects; this did not affect the clonidine-induced GH release.
Neg (not) Regulation (affect) of Localization (release) of GH associated with clonidine
20) Confidence 0.53 Published 1986 Journal Psychoneuroendocrinology Section Abstract Doc Link 3786637 Disease Relevance 0 Pain Relevance 0.60

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