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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (UGCG) transferase activity, transferring glycosyl groups (UGCG) Golgi apparatus (UGCG)
Anatomy Link Frequency
puncture 2
UGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
Versed 1 44.28 Quite Low
drug abuse 1 11.20 Low Low
alcohol 1 10.64 Low Low
Inflammation 15 5.00 Very Low Very Low Very Low
Electroencephalography 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lumbar Puncture Related Headaches 2 99.90 Very High Very High Very High
Infection 6 97.20 Very High Very High Very High
Sleep Disorders 7 81.44 Quite High
Coma 5 78.48 Quite High
Stress 5 56.92 Quite High
Sepsis 38 50.00 Quite Low
Encephalopathy 36 50.00 Quite Low
Gauchers Disease 68 44.56 Quite Low
Targeted Disruption 1 37.36 Quite Low
Lysosomal Storage Diseases 1 35.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, taliglucerase does not require exposure of mannose residues in vitro, which is a requirement for the production of other recombinant GCs.53 Nevertheless, higher number of mannose residues may result in increased immunogenicity due to the presentation of nonmammalian glycans.54 However, there have been no clinical adverse effects, nor increased frequency of neutralizing antibodies associated with taliglucerase during safety and pharmacokinetics studies.54 Recently, there has been serious problems in the manufacturing and processing of imiglucerase, and availability of alternative therapeutics has become more pressing than ever.
Positive_regulation (requirement) of Gene_expression (production) of GCs
1) Confidence 0.09 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 0 Pain Relevance 0
A lumbar puncture was performed in all patients with a GCS ?
Positive_regulation (performed) of Gene_expression (performed) of GCS in puncture associated with lumbar puncture related headaches
2) Confidence 0.07 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 0.41 Pain Relevance 0

General Comments

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