INT316126

Context Info Confidence 0.12 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.22 Pain Relevance 0.13

extracellular space (IL10, CD14) extracellular region (IL10, CD14) plasma membrane (CD14) intracellular (IL10) cell-cell signaling (IL10) response to stress (IL10)

Anatomy Link Frequency monocyte 1 IL10 (Homo sapiens) CD14 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 4 86.56 Inflammation 13 55.84 Inflammatory response 6 16.56 anesthesia 17 5.00 antagonist 4 5.00 Enkephalin 3 5.00 substance P 3 5.00 cva 3 5.00 Neurotransmitter 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 16 55.84 Stress 5 53.92 Pressure Volume 2 Under Development 2 11.28 Systemic Inflammatory Response Syndrome 7 5.00 Sepsis 7 5.00 Injury 5 5.00 Infection 5 5.00 Pancreatitis 4 5.00 Cv General 3 Under Development 3 5.00 Burns 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In agreement with our in vivo observations, we showed that hydrocortisone was able to down-regulate HLA-DR expression on both monocyte subpopulations, whereas IL-10 only acted on CD14HIGH monocytes.

IL-10 Regulation (acted) of CD14HIGH in monocyte

1) Confidence 0.12 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.22 Pain Relevance 0.13

General Comments

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