INT316151

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 2.32
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (MARCH1) Golgi apparatus (MARCH1) plasma membrane (MARCH1)
ligase activity (MARCH1) lysosome (MARCH1)
Anatomy Link Frequency
monocytes 3
MARCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 136 98.48 Very High Very High Very High
antagonist 32 96.64 Very High Very High Very High
Inflammation 104 93.88 High High
cva 24 69.32 Quite High
agonist 8 40.68 Quite Low
cytokine 32 30.20 Quite Low
Enkephalin 24 22.56 Low Low
substance P 24 21.92 Low Low
Inflammatory response 48 18.32 Low Low
Neurotransmitter 8 12.40 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 128 93.88 High High
Critical Illness 8 91.52 High High
Nosocomial And Community Acquired Bacterial Infections 16 86.16 High High
Injury 40 80.44 Quite High
Burns 24 80.16 Quite High
Pancreatitis 32 79.60 Quite High
Infection 40 75.40 Quite High
Cv General 3 Under Development 24 69.32 Quite High
Sepsis 56 62.96 Quite High
Hemorrhagic Shock 16 44.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative real-time PCR for MARCH1 gene expression
Gene_expression (expression) of MARCH1 gene
1) Confidence 0.55 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.15
In parallel, IL-10 was shown to up-regulate the membrane-associated RING-CH-1 protein (MARCH1) [23], an ubiquitin E3 ligase that promotes the ubiquination and internalization of the HLA-DR ?
Gene_expression (protein) of MARCH1
2) Confidence 0.47 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 1.03 Pain Relevance 0.08
Expression of MARCH1 in monocytes of healthy controls in the presence of hydrocortisone, and in monocytes of AAS patients after surgery
Gene_expression (Expression) of MARCH1 in monocytes
3) Confidence 0.42 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.11
In the present study, we showed for the first time the capacity of glucocorticoids to up-regulate the expression of MARCH1 mRNA in monocytes from healthy controls.
Gene_expression (expression) of MARCH1 mRNA in monocytes
4) Confidence 0.42 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.13 Pain Relevance 0.04
Similarly, in AAS patients MARCH1 gene expression was increased at POD1 as compared to T1 (Figure 9B).


Gene_expression (expression) of MARCH1 gene associated with anesthesia
5) Confidence 0.42 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.06 Pain Relevance 0.17
As shown in Figure 9A, incubation of whole blood from healthy donors with hydrocortisone led to a three-fold increase in MARCH1 gene expression in their monocytes after 24 hours of incubation.
Gene_expression (expression) of MARCH1 gene in monocytes
6) Confidence 0.42 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.06 Pain Relevance 0.16
Finally, in order to gain insight into the mechanism of HLA-DR down-regulation by glucocorticoids, we analyzed the expression of MARCH1.
Spec (analyzed) Gene_expression (expression) of MARCH1
7) Confidence 0.42 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0
In parallel, IL-10 was shown to up-regulate the membrane-associated RING-CH-1 protein (MARCH1) [23], an ubiquitin E3 ligase that promotes the ubiquination and internalization of the HLA-DR ?
Gene_expression (protein) of membrane-associated RING-CH-1
8) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 1.04 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox