INT316152

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRA) Golgi apparatus (HLA-DRA) endoplasmic reticulum (HLA-DRA)
plasma membrane (HLA-DRA) lysosome (HLA-DRA)
Anatomy Link Frequency
monocytes 2
HLA-DRA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 26 98.74 Very High Very High Very High
agonist 2 81.36 Quite High
cva 6 72.92 Quite High
Enkephalin 6 63.24 Quite High
substance P 6 62.60 Quite High
Neurotransmitter 2 53.08 Quite High
antagonist 8 34.84 Quite Low
cytokine 8 26.76 Quite Low
Inflammatory response 12 21.92 Low Low
anesthesia 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 98.74 Very High Very High Very High
Critical Illness 2 95.12 Very High Very High Very High
Nosocomial And Community Acquired Bacterial Infections 4 89.76 High High
Injury 10 84.04 Quite High
Burns 6 83.76 Quite High
Pancreatitis 8 83.20 Quite High
Infection 10 79.00 Quite High
Cv General 3 Under Development 6 72.92 Quite High
Sepsis 14 62.28 Quite High
Hemorrhagic Shock 4 47.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As compared to IL-10, hydrocortisone had a greater capacity to reduce the up-regulation of HLA-DR induced by PAMPs, especially on CD14HIGH monocytes.
Negative_regulation (reduce) of Regulation (regulation) of HLA-DR in monocytes
1) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.16
Among the mediators produced during inflammation, cortisol [21] and IL-10 [22] were shown to contribute to the down-regulation of HLA-DR on CD14+ cells.
Negative_regulation (down) of Regulation (regulation) of HLA-DR associated with inflammation
2) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 1.13 Pain Relevance 0.09

General Comments

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