INT316154

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.22
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TCF21) DNA binding (TCF21)
Anatomy Link Frequency
blood 2
plasma 1
TCF21 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 69 95.98 Very High Very High Very High
addiction 36 87.00 High High
Pain 3 73.44 Quite High
Morphine 3 73.00 Quite High
analgesia 3 70.28 Quite High
Paracetamol 3 69.16 Quite High
Inflammation 75 68.36 Quite High
Versed 3 44.96 Quite Low
iatrogenic 3 44.40 Quite Low
antagonist 12 40.84 Quite Low
Disease Link Frequency Relevance Heat
Systemic Inflammatory Response Syndrome 87 88.12 High High
Pneumonia 24 85.28 High High
Anastomotic Leak 27 83.64 Quite High
Pain 3 73.44 Quite High
INFLAMMATION 87 68.36 Quite High
Adult Respiratory Distress Syndrome 60 63.84 Quite High
Cancer 18 55.12 Quite High
Recurrence 3 54.56 Quite High
Malignant Neoplastic Disease 6 50.92 Quite High
Esophageal Cancer 39 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both groups of patients showed a significant increase in plasma levels of cortisol at POD1 (Table 1), in agreement with previous studies, which reported peak level of cortisol one day after surgery [36,37].
Positive_regulation (increase) of POD1 in plasma
1) Confidence 0.17 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.07 Pain Relevance 0.29
POD 1 upregulation of PDGFA, ERG1, and HMGB1 mRNA correlated significantly with worse prognosis.
Positive_regulation (upregulation) of POD 1
2) Confidence 0.13 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.26 Pain Relevance 0.11
Blood samples from patients were collected into sodium citrate vacuum tubes as follows: immediately before anesthesia induction (T1); before incision (T2), before vascular clamping (aortic clamping (AAS patients) or carotid artery clamping (CAS patients)) (T3), after blood reperfusion (T4) during the surgery, and on postoperative Days 1 (POD1) and 2 (POD2) after the surgery.
Positive_regulation (postoperative) of POD1 in blood associated with anesthesia
3) Confidence 0.12 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.07 Pain Relevance 0.38
Blood samples from patients were collected into sodium citrate vacuum tubes as follows: immediately before anesthesia induction (T1); before incision (T2), before vascular clamping (aortic clamping (AAS patients) or carotid artery clamping (CAS patients)) (T3), after blood reperfusion (T4) during the surgery, and on postoperative Days 1 (POD1) and 2 (POD2) after the surgery.
Positive_regulation (postoperative) of POD2 in blood associated with anesthesia
4) Confidence 0.10 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.07 Pain Relevance 0.38
Upregulation of EGR and NAMPT mRNA at POD 1, 3 and 14 indicates that we should become more clinically astute in the immediate postoperative period.
Positive_regulation (Upregulation) of POD 1
5) Confidence 0.09 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.56 Pain Relevance 0.07
At POD 1, CRP mRNA upregulation was accompanied by increased serum CRP levels; these decreased at POD 3 following appropriate treatment (data not shown).
Positive_regulation (upregulation) of POD 1
6) Confidence 0.05 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.18 Pain Relevance 0

General Comments

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