INT316156

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (MARCH1) Golgi apparatus (MARCH1) plasma membrane (MARCH1)
ligase activity (MARCH1) lysosome (MARCH1)
Anatomy Link Frequency
monocytes 1
MARCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 8 87.56 High High
Inflammation 26 79.68 Quite High
anesthesia 34 75.92 Quite High
agonist 2 31.60 Quite Low
cytokine 8 15.12 Low Low
Enkephalin 6 13.48 Low Low
substance P 6 12.84 Low Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 79.68 Quite High
Sepsis 14 66.96 Quite High
Injury 10 22.96 Low Low
Pancreatitis 8 20.40 Low Low
Burns 6 19.28 Low Low
Stress 10 19.12 Low Low
Hemorrhagic Shock 4 18.80 Low Low
Nosocomial And Community Acquired Bacterial Infections 4 7.60 Low Low
Systemic Inflammatory Response Syndrome 14 5.00 Very Low Very Low Very Low
Infection 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of the known role of MARCH1 on HLA-DR trafficking [24,25], we investigated whether MARCH1 was modulated by glucocorticoids.
Spec (whether) Regulation (modulated) of MARCH1
1) Confidence 0.19 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.12
Most importantly, we observed an up-regulation of MARCH1 mRNA in vivo in monocytes from AAS patients one day after surgery.


Regulation (regulation) of MARCH1 mRNA in monocytes
2) Confidence 0.19 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.15 Pain Relevance 0.04

General Comments

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