INT316165

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.12
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (MARCH1) Golgi apparatus (MARCH1) plasma membrane (MARCH1)
ligase activity (MARCH1) lysosome (MARCH1)
Anatomy Link Frequency
monocytes 2
MARCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 34 99.04 Very High Very High Very High
antagonist 8 81.56 Quite High
Inflammation 26 65.36 Quite High
agonist 2 25.60 Quite Low
cva 6 10.32 Low Low
Enkephalin 6 7.48 Low Low
substance P 6 6.84 Low Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 65.36 Quite High
Injury 10 45.12 Quite Low
Sepsis 14 43.20 Quite Low
Pancreatitis 8 42.56 Quite Low
Burns 6 41.44 Quite Low
Hemorrhagic Shock 4 40.96 Quite Low
Nosocomial And Community Acquired Bacterial Infections 4 29.76 Quite Low
Stress 10 12.32 Low Low
Cv General 3 Under Development 6 10.32 Low Low
Systemic Inflammatory Response Syndrome 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 9A, incubation of whole blood from healthy donors with hydrocortisone led to a three-fold increase in MARCH1 gene expression in their monocytes after 24 hours of incubation.
Positive_regulation (increase) of Gene_expression (expression) of MARCH1 gene in monocytes
1) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.06 Pain Relevance 0.16
Similarly, in AAS patients MARCH1 gene expression was increased at POD1 as compared to T1 (Figure 9B).


Positive_regulation (increased) of Gene_expression (expression) of MARCH1 gene associated with anesthesia
2) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.07 Pain Relevance 0.17

General Comments

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