INT316203

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.50
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agrp) signal transduction (Ghsr) plasma membrane (Ghsr)
signal transducer activity (Ghsr)
Anatomy Link Frequency
neurons 1
gut 1
Ghsr (Mus musculus)
Agrp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 99.76 Very High Very High Very High
cytokine 13 75.16 Quite High
Inflammation 5 74.80 Quite High
medulla 1 42.04 Quite Low
Central nervous system 1 20.64 Low Low
antagonist 3 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 45 97.12 Very High Very High Very High
Cancer 5 96.76 Very High Very High Very High
Myocardial Infarction 104 93.96 High High
Acute Renal Failure 1 91.24 High High
Sepsis 1 88.32 High High
Chronic Disease 4 80.84 Quite High
INFLAMMATION 5 74.80 Quite High
Weight Gain 5 61.88 Quite High
Weight Loss 3 52.28 Quite High
Disease 1 46.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ghrelin, a gut-derived peptide agonist for the GH secretagogue receptor that also potently inhibits central melanocortin signaling by increasing Agrp mRNA expression (Kamegai et al. 2000) and hyperpolarizing POMC neurons (Cowley et al. 2003), has been shown to attenuate the development of cachexia in rat models of CHF (Nagaya et al. 2001).
secretagogue receptor Positive_regulation (increasing) of in neurons Transcription (expression) of Agrp in gut associated with appetite loss, agonist and myocardial infarction
1) Confidence 0.02 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 1.50 Pain Relevance 0.19

General Comments

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