INT316205

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MC3R) signal transducer activity (MC3R)
Anatomy Link Frequency
MC3 2
MC3R (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 99.84 Very High Very High Very High
cytokine 13 98.70 Very High Very High Very High
Neuropeptide 2 72.92 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 1 93.56 High High
Appetite Loss 45 79.44 Quite High
Myocardial Infarction 104 77.64 Quite High
Hypertrophy 2 75.36 Quite High
Hyperphagia 1 70.08 Quite High
Metabolic Syndrome 2 69.76 Quite High
Cardiovascular Disorder Under Development 1 61.56 Quite High
Cardiovascular Disease 1 50.48 Quite High
Overweight 1 40.24 Quite Low
Obesity 1 39.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of MC3R led to reduced myocardial cytokine production and myeloperoxidase activity, and these effects were prevented by the mixed MC3/4R antagonist SHU9119, but not by the selective MC4R antagonist HS204 (Getting et al. 2004).
Negative_regulation (prevented) of MC3 Binding (mixed) of in MC3 associated with antagonist and cytokine
1) Confidence 0.41 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.89 Pain Relevance 0.18

General Comments

This test has worked.

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