INT316290

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.84
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ddah2)
Anatomy Link Frequency
lungs 2
Ddah2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 5 98.38 Very High Very High Very High
Inflammatory response 15 84.92 Quite High
Morphine 5 37.16 Quite Low
fibrosis 10 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Peripheral nervous system 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 145 99.96 Very High Very High Very High
Apoptosis 140 99.40 Very High Very High Very High
INFLAMMATION 20 98.22 Very High Very High Very High
Pulmonary Hypertension 10 97.52 Very High Very High Very High
Viral Infection 30 93.12 High High
Disease 30 77.64 Quite High
Communicable Diseases 5 77.48 Quite High
Autoimmune Disease 5 73.24 Quite High
Death 15 60.84 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 35 52.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, expression of DDAH2 was also found to be reduced when comparing lung tissue from pulmonary hypertensive rats and idiopathic pulmonary arterial hypertension (IPAH) patients to corresponding normal lung tissue [49].
Gene_expression (expression) of DDAH2 in lung associated with pulmonary hypertension
1) Confidence 0.28 Published 2010 Journal Virol J Section Body Doc Link PMC2887434 Disease Relevance 0.81 Pain Relevance 0.12
The recent study has indicated that the activity of DDAH and the expression of DDAH2 (mRNA and protein) was significantly decreased in cobalt chloride (CoCl2)-induced apoptosis.
Gene_expression (expression) of DDAH2 associated with apoptosis
2) Confidence 0.28 Published 2010 Journal Virol J Section Body Doc Link PMC2887434 Disease Relevance 0.78 Pain Relevance 0.04
Various oxidative, LPS, or inflammatory stimuli could directly inactivate the DDAH activity and then significantly decrease the expression of DDAH2 mRNA and protein through a sulfhydryl group in the catalytic region of DDAH [48].
Gene_expression (expression) of DDAH2 associated with inflammatory stimuli
3) Confidence 0.28 Published 2010 Journal Virol J Section Body Doc Link PMC2887434 Disease Relevance 0.84 Pain Relevance 0.13
In contrast, DDAH2 overexpression inhibited the proapoptotic effects of CoCl2 [47].
Gene_expression (overexpression) of DDAH2
4) Confidence 0.22 Published 2010 Journal Virol J Section Body Doc Link PMC2887434 Disease Relevance 0.78 Pain Relevance 0.07
These results strongly support the importance of DDAH2 in N-PRRSV pathogenesis, and after N-PRRSV infection, expression of DDAH2 in lungs significantly decreased comparing to those in uninfected negative control lungs, which resulted in cell-infected apoptosis, which might be a host defense against viral infection.


Gene_expression (expression) of DDAH2 in lungs associated with viral infection, apoptosis and infection
5) Confidence 0.19 Published 2010 Journal Virol J Section Body Doc Link PMC2887434 Disease Relevance 0.63 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox