INT3163

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Context Info
Confidence 0.75
First Reported 1978
Last Reported 2008
Negated 1
Speculated 2
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 15.23
Pain Relevance 4.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (NAGLU) lysosome (NAGLU)
Anatomy Link Frequency
urine 8
blood 2
spinal 2
leucocyte 2
Clara cell 2
NAGLU (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 17 100.00 Very High Very High Very High
anesthesia 21 99.94 Very High Very High Very High
rheumatoid arthritis 4 98.60 Very High Very High Very High
agonist 1 97.80 Very High Very High Very High
Buprenorphine 1 97.44 Very High Very High Very High
Analgesic 20 97.40 Very High Very High Very High
alcohol 25 96.44 Very High Very High Very High
aspirin 22 96.20 Very High Very High Very High
Restless leg syndrome 120 95.76 Very High Very High Very High
Paracetamol 5 94.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 45 100.00 Very High Very High Very High
Diabetes Mellitus 43 100.00 Very High Very High Very High
Cyst 6 100.00 Very High Very High Very High
Sprains And Strains 5 99.98 Very High Very High Very High
Pressure And Volume Under Development 33 99.92 Very High Very High Very High
Diuresis 5 99.92 Very High Very High Very High
Hypotension 8 99.72 Very High Very High Very High
Pressure Volume 2 Under Development 1 99.66 Very High Very High Very High
Vomiting 9 99.40 Very High Very High Very High
Disorders Of Creatine Metabolism 64 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
expression of the nonsteroidal anti-inflammatory drug-activated gene (NAG1)

[22].

Gene_expression (expression) of NAG1 associated with inflammation and cinod
1) Confidence 0.75 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.29 Pain Relevance 0.10
Excretion of the brush border enzyme GGT, the cytoplasm enzyme LDH, and the lysosomal enzymes, NAG and GAL, was analysed before, during and after ingestion of the analgesics.
Spec (analysed) Gene_expression (Excretion) of NAG in brush associated with analgesic
2) Confidence 0.65 Published 1986 Journal Clin. Chim. Acta Section Abstract Doc Link 2877759 Disease Relevance 0.17 Pain Relevance 0.43
The urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) was elevated in four patients; two had other biochemical evidence of renal damage while the other two patients appeared normal, although they had both received spinal irradiation in the past.
Gene_expression (excretion) of N-acetyl-beta-D-glucosaminidase in spinal
3) Confidence 0.59 Published 1987 Journal Br. J. Rheumatol. Section Abstract Doc Link 3664158 Disease Relevance 0.95 Pain Relevance 0.54
The urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) was elevated in four patients; two had other biochemical evidence of renal damage while the other two patients appeared normal, although they had both received spinal irradiation in the past.
Gene_expression (excretion) of NAG in spinal
4) Confidence 0.59 Published 1987 Journal Br. J. Rheumatol. Section Abstract Doc Link 3664158 Disease Relevance 0.95 Pain Relevance 0.54
N-acetyl-beta-glucosaminidase (EC 3.2.1.30, recommended name beta-N-Acetylglucosaminidase) was found to be a constituent of human cardiac lysosomes. beta-glucuronidase was also found in this tissue, while lysozyme, an enzyme present in leucocyte lysosomes, was not detectable in the heart.
Gene_expression (found) of N-acetyl-beta-glucosaminidase in leucocyte
5) Confidence 0.56 Published 1978 Journal Cardiovasc. Res. Section Abstract Doc Link 647716 Disease Relevance 0.29 Pain Relevance 0.14
Association of levels of N-acetyl-beta-glucosaminidase with specific psychiatric symptoms in bipolar patients.
Gene_expression (levels) of N-acetyl-beta-glucosaminidase
6) Confidence 0.55 Published 1993 Journal Psychiatry Res Section Title Doc Link 8341766 Disease Relevance 0.50 Pain Relevance 0.15
The levels of N-acetyl-beta-glucosaminidase (NAG) in urine from 35 patients with bipolar affective disorder were compared with scores for the 90 items (symptoms) of the Symptom Checklist (SCL-90).
Gene_expression (levels) of NAG in urine associated with manic depressive disorder
7) Confidence 0.55 Published 1993 Journal Psychiatry Res Section Abstract Doc Link 8341766 Disease Relevance 0.44 Pain Relevance 0.12
The levels of N-acetyl-beta-glucosaminidase (NAG) in urine from 35 patients with bipolar affective disorder were compared with scores for the 90 items (symptoms) of the Symptom Checklist (SCL-90).
Gene_expression (levels) of N-acetyl-beta-glucosaminidase in urine associated with manic depressive disorder
8) Confidence 0.55 Published 1993 Journal Psychiatry Res Section Abstract Doc Link 8341766 Disease Relevance 0.44 Pain Relevance 0.12
The urinary excretion of two proteins, B-2-microglobulin (beta 2M) and N-acetyl-B-D-glucosaminidase (NAG) was measured in 25 patients with rheumatoid arthritis (RA) on nonsteroidal anti-inflammatory drugs (NSAID).
Gene_expression (excretion) of NAG associated with inflammation, cinod and rheumatoid arthritis
9) Confidence 0.53 Published 1983 Journal Clin. Rheumatol. Section Abstract Doc Link 6432404 Disease Relevance 0.73 Pain Relevance 0.48
The levels of NAG, beta 2MG and urinary protein in the HM3 series were higher than those of the modified HM3 series.
Gene_expression (levels) of NAG
10) Confidence 0.52 Published 1991 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 2072608 Disease Relevance 0.27 Pain Relevance 0.11
Molecular basis of MPS II
Gene_expression (basis) of MPS II
11) Confidence 0.48 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC2234442 Disease Relevance 0.24 Pain Relevance 0
NAG was expressed as a ratio with urinary creatinine so as to adjust for differences in urinary flow of the sample (i.e. ?
Gene_expression (expressed) of NAG associated with diuresis
12) Confidence 0.41 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.10 Pain Relevance 0
Glucose, protein, albumin, N-acetyl-beta-D-glucosaminidase (NAG), and alpha- and pi-glutathione-S-transferase (GST) levels were analyzed in urine collected at 24 h before and for 3 days after sevoflurane anesthesia.
Gene_expression (levels) of N-acetyl-beta-D-glucosaminidase in urine
13) Confidence 0.38 Published 1998 Journal Anesthesiology Section Body Doc Link 9523801 Disease Relevance 0 Pain Relevance 0
Glucose, protein, albumin, N-acetyl-beta-D-glucosaminidase (NAG), and alpha- and pi-glutathione-S-transferase (GST) levels were analyzed in urine collected at 24 h before and for 3 days after sevoflurane anesthesia.
Gene_expression (levels) of NAG in urine
14) Confidence 0.38 Published 1998 Journal Anesthesiology Section Body Doc Link 9523801 Disease Relevance 0 Pain Relevance 0
The following parameters were measured: plasma interleukin-6 (IL-6), high sensitivity CRP (hsCRP), white blood cell count, thrombin-anti-thrombin complex (TAT) and fibrin D-Dimer (fDD), urinary protein creatinine ratio (PCR), ACR and NAG.


Gene_expression (measured) of NAG in white blood cell
15) Confidence 0.36 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.52 Pain Relevance 0.51
Glucose, protein, albumin, N-acetyl-beta-D-glucosaminidase (NAG), and alpha- and pi-glutathione-S-transferase (GST) levels were analyzed in urine collected at 24 h before and for 3 days after sevoflurane anesthesia.
Gene_expression (levels) of N-acetyl-beta-D-glucosaminidase in urine
16) Confidence 0.33 Published 1998 Journal Anesthesiology Section Body Doc Link 9523801 Disease Relevance 0 Pain Relevance 0
Glucose, protein, albumin, N-acetyl-beta-D-glucosaminidase (NAG), and alpha- and pi-glutathione-S-transferase (GST) levels were analyzed in urine collected at 24 h before and for 3 days after sevoflurane anesthesia.
Spec (analyzed) Gene_expression (Glucose) of NAG in urine
17) Confidence 0.33 Published 1998 Journal Anesthesiology Section Body Doc Link 9523801 Disease Relevance 0 Pain Relevance 0
NAG and RBP models were adjusted for age, sex, BMI, systolic blood pressure, current/former worker status, alcohol ingestion, and diabetes. 41 ?
Gene_expression (models) of NAG in blood associated with diabetes mellitus and alcohol
18) Confidence 0.33 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253707 Disease Relevance 0.83 Pain Relevance 0.05
Finally, in the oldest tertile of workers, associations between lead dose and NAG were unchanged, but fewer associations between the lead biomarkers and the clinical renal outcomes remained significant (p ?
Gene_expression (dose) of NAG
19) Confidence 0.33 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1253707 Disease Relevance 0.07 Pain Relevance 0.04
Urine creatinine was measured in spot samples (for adjustment of NAG and RBP) and in the 4-hr sample after DMSA (for determination of measured creatinine clearance and adjustment of DMSA-chelatable lead levels), using a modification of the Sigma kit (Sigma Chemical Company, St.
Gene_expression (adjustment) of NAG in Urine associated with disorders of creatine metabolism
20) Confidence 0.33 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253707 Disease Relevance 0.24 Pain Relevance 0

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