INT316363

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.66
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr3c2) DNA binding (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
vasculature 1
heart 1
kidney 1
Nr3c2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 9 93.68 High High
fibrosis 6 83.84 Quite High
chemokine 3 76.24 Quite High
Bioavailability 3 70.44 Quite High
antagonist 15 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
beta blocker 3 5.00 Very Low Very Low Very Low
Calcium channel 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 9 97.08 Very High Very High Very High
Stress 3 94.48 High High
Vasculitis 3 94.04 High High
Chronic Renal Failure 192 92.52 High High
Renal Disease 69 88.52 High High
INFLAMMATION 6 78.88 Quite High
Adhesions 3 76.96 Quite High
Cv Unclassified Under Development 54 61.04 Quite High
Disease 24 35.76 Quite Low
Diabetes Mellitus 84 34.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to its well known actions in promoting Na+ reabsorption by the kidney, there is now clear evidence that aldosterone-mediated activation of the mineralocorticoid receptor in non-epithelial tissues of the heart, kidney, and vasculature induces fibrotic changes in these tissues [25], contributes to oxidative stress and vascular inflammation [26], and is associated with endothelial dysfunction [27].


Positive_regulation (activation) of mineralocorticoid receptor in vasculature associated with stress, fibrosis, inflammation and vasculitis
1) Confidence 0.11 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.89 Pain Relevance 0.23
In addition to its well known actions in promoting Na+ reabsorption by the kidney, there is now clear evidence that aldosterone-mediated activation of the mineralocorticoid receptor in non-epithelial tissues of the heart, kidney, and vasculature induces fibrotic changes in these tissues [25], contributes to oxidative stress and vascular inflammation [26], and is associated with endothelial dysfunction [27].


Positive_regulation (activation) of mineralocorticoid receptor in heart associated with stress, fibrosis, inflammation and vasculitis
2) Confidence 0.04 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.89 Pain Relevance 0.23
In addition to its well known actions in promoting Na+ reabsorption by the kidney, there is now clear evidence that aldosterone-mediated activation of the mineralocorticoid receptor in non-epithelial tissues of the heart, kidney, and vasculature induces fibrotic changes in these tissues [25], contributes to oxidative stress and vascular inflammation [26], and is associated with endothelial dysfunction [27].


Positive_regulation (activation) of mineralocorticoid receptor in kidney associated with stress, fibrosis, inflammation and vasculitis
3) Confidence 0.04 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.89 Pain Relevance 0.23

General Comments

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