INT316368

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Anatomy Link Frequency
plasma 4
sympathetic 2
juxtaglomerular cells 2
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 20 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
beta blocker 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 72 96.72 Very High Very High Very High
Diabetes Mellitus 112 96.04 Very High Very High Very High
Chronic Renal Failure 256 85.92 High High
Proteinuria 84 84.32 Quite High
Disease 32 76.12 Quite High
Disease Progression 4 75.00 Quite High
Albuminuria 8 65.28 Quite High
Renal Disease 92 54.96 Quite High
Death 24 40.28 Quite Low
Increased Venous Pressure Under Development 4 16.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This phenomenon has been termed “ACE escape” and is likely due to a compensatory increase in plasma renin activity due to disruption of the feedback loop by which Ang II normally inhibits renin release [12].
Negative_regulation (inhibits) of Localization (release) of renin in plasma
1) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.70 Pain Relevance 0
Renin is stored in secretory granules and is released in response to decreases in renal perfusion pressure, decreases in Cl- in the distal tubule fluid or increased sympathetic nerve stimulation via ?
Negative_regulation (decreases) of Localization (released) of Renin in sympathetic
2) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.37 Pain Relevance 0
Renin release can also be inhibited by a direct action of angiotensin II on the juxtaglomerular cells.
Negative_regulation (inhibited) of Localization (release) of Renin in juxtaglomerular cells
3) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.32 Pain Relevance 0
Likewise, ARBs increase plasma renin activity due to inhibition of the Ang II-renin release feedback loop [46].
Negative_regulation (inhibition) of Localization (release) of renin in plasma
4) Confidence 0.24 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.76 Pain Relevance 0

General Comments

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