INT316401

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.63
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npc1l1)
Anatomy Link Frequency
Caco-2 1
Npc1l1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 2 70.84 Quite High
Angina 8 5.00 Very Low Very Low Very Low
Percutaneous transluminal coronary angioplasty 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dyslipidemia /

Combined Dyslipidemia

4 94.68 High High
Diabetes Mellitus 90 94.04 High High
Disorder Of Lipid Metabolism 22 72.56 Quite High
Cv Unclassified Under Development 46 59.96 Quite High
Disorders Of Creatine Metabolism 14 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 8 5.00 Very Low Very Low Very Low
Myocardial Infarction 6 5.00 Very Low Very Low Very Low
Hyperlipidemia 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to differences in NPC1L1 protein expression, a disturbance in the ATP binding cassette (ABC) proteins G5 and G8, which regulate cholesterol homeostasis, may play a role in the dyslipidemia of diabetic patients.
Gene_expression (expression) of NPC1L1 protein associated with diabetes mellitus
1) Confidence 0.17 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2887787 Disease Relevance 0.77 Pain Relevance 0.03
Cultured Caco-2/15 cells exposed to high glucose levels displayed a significant increase in protein expression of NPC1L1, and when ezetimibe was added to the culture medium, the action of the glucose was reduced [31].
Gene_expression (expression) of NPC1L1 in Caco-2
2) Confidence 0.17 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2887787 Disease Relevance 0.69 Pain Relevance 0.04

General Comments

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