INT316410

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.62
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npc1l1)
Npc1l1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 2 78.44 Quite High
Angina 8 5.00 Very Low Very Low Very Low
Percutaneous transluminal coronary angioplasty 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 90 99.84 Very High Very High Very High
Disorder Of Lipid Metabolism 22 97.80 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

4 91.88 High High
Cv Unclassified Under Development 46 67.56 Quite High
Disorders Of Creatine Metabolism 14 24.88 Low Low
Cv General 3 Under Development 8 5.00 Very Low Very Low Very Low
Myocardial Infarction 6 5.00 Very Low Very Low Very Low
Hyperlipidemia 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One mechanism by which NPC1L1 may be increased in T2DM patients is through elevated glucose concentrations [31].
Positive_regulation (increased) of NPC1L1 associated with diabetes mellitus
1) Confidence 0.15 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2887787 Disease Relevance 0.68 Pain Relevance 0.04
Taken together, these results suggest that both increased NPC1L1 and lower ABCG5 and G8 may lead to an increase in cholesterol absorption in diabetic patients, and targeting both the synthesis and the intestinal absorption of cholesterol in the treatment of diabetic dyslipidemia may be prudent.
Positive_regulation (increased) of NPC1L1 associated with diabetes mellitus
2) Confidence 0.15 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2887787 Disease Relevance 0.69 Pain Relevance 0

General Comments

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