INT316432

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.33
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il11) extracellular region (Il11) cytoplasm (Il11)
Anatomy Link Frequency
intestine 1
Il11 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 196 100.00 Very High Very High Very High
rheumatoid arthritis 124 99.28 Very High Very High Very High
antagonist 5 89.12 High High
Inflammatory response 25 80.96 Quite High
Arthritis 6 75.00 Quite High
Inflammation 52 72.08 Quite High
chemokine 2 29.60 Quite Low
agonist 1 26.12 Quite Low
visual analogue scale 18 10.08 Low Low
Pain 18 9.92 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 127 99.28 Very High Very High Very High
Cancer 152 96.80 Very High Very High Very High
Leukemia 6 94.72 High High
Disease 92 88.44 High High
Arthropathy 6 84.00 Quite High
INFLAMMATION 77 80.96 Quite High
Anaemia 3 75.48 Quite High
Fever 3 75.08 Quite High
Apoptosis 11 48.32 Quite Low
Infection 2 46.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies suggest that some of the IL-6 family cytokines such as IL-6, IL-11, and LIF could be related with RA.
Positive_regulation (some) of IL-11 associated with rheumatoid arthritis and cytokine
1) Confidence 0.32 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.11 Pain Relevance 0.75
Serum concentrations of IL-6 family cytokines, including IL-6, IL-11, and LIF, were significantly elevated in patients with RA compared to those of healthy controls.
Positive_regulation (elevated) of IL-11 associated with rheumatoid arthritis and cytokine
2) Confidence 0.30 Published 2011 Journal Yonsei Medical Journal Section Abstract Doc Link PMC3017685 Disease Relevance 1.13 Pain Relevance 0.51
The current study showed that serum concentrations of IL-6, IL-11, and LIF were significantly elevated in patients with RA compared to those in healthy controls.
Positive_regulation (elevated) of IL-11 associated with rheumatoid arthritis
3) Confidence 0.13 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 0.73 Pain Relevance 0.47
Although the two pathways share transcriptional responsiveness of proliferative target genes, such as c-myc and cyclinD1, IL11 administration and excessive Stat3 activation also facilitates survival of epithelial cells with the capacity to repopulate the intestine after radiation damage [92] (Phesse T, Buchert M, Ernst M: Epistatic interaction between aberrant Wnt and Stat3 signaling during intestinal tumorigenesis, submitted).
Positive_regulation (responsiveness) of IL11 in intestine
4) Confidence 0.13 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.37 Pain Relevance 0

General Comments

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