INT31648

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 1999
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 16
Disease Relevance 2.09
Pain Relevance 5.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
brain 4
brain stem 1
forebrain 1
parasympathetic 1
central nervous system 1
Trh (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 6 100.00 Very High Very High Very High
antinociception 3 100.00 Very High Very High Very High
Central nervous system 2 100.00 Very High Very High Very High
anesthesia 9 99.76 Very High Very High Very High
opiate 13 99.74 Very High Very High Very High
Opioid 3 99.60 Very High Very High Very High
melanocortin 1 receptor 6 99.24 Very High Very High Very High
Catecholamine 2 98.84 Very High Very High Very High
Morphine 8 97.56 Very High Very High Very High
agonist 6 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anaphylaxis 5 100.00 Very High Very High Very High
Experimental Melanoma 12 97.44 Very High Very High Very High
Hyperglycemia 4 92.76 High High
Pain 2 87.12 High High
Shock 2 77.04 Quite High
Hypothermia 2 61.44 Quite High
Hypoglycemia 1 59.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRH did not modify the binding of [3H]naloxone in mouse brain either in vitro (TRH: 10(-10)-10(-4) M) or ex vivo (TRH: 1-40 mg kg-1 i.p.).
TRH Binding (binding) of in brain associated with narcan
1) Confidence 0.48 Published 1987 Journal Gen. Pharmacol. Section Abstract Doc Link 3032733 Disease Relevance 0 Pain Relevance 0.47
The antihyperglycemic effect was dose-related, dependent upon the structural integrity of the peptide, dissociated from the peptide's hypophysiotropic action and from its interaction with TRH receptors, and mediated by the cholinergic parasympathetic system.
TRH Binding (interaction) of in parasympathetic
2) Confidence 0.48 Published 1988 Journal Peptides Section Abstract Doc Link 2896345 Disease Relevance 0.37 Pain Relevance 0.21
Thyrotropin releasing hormone (TRH) selectively binds and activates the melanocortin 1 receptor.
TRH Binding (binds) of associated with melanocortin 1 receptor
3) Confidence 0.43 Published 1999 Journal Peptides Section Title Doc Link 10447100 Disease Relevance 0.17 Pain Relevance 0.10
Thyrotropin releasing hormone (TRH) selectively binds and activates the melanocortin 1 receptor.
Thyrotropin releasing hormone Binding (binds) of associated with melanocortin 1 receptor
4) Confidence 0.43 Published 1999 Journal Peptides Section Title Doc Link 10447100 Disease Relevance 0.17 Pain Relevance 0.10
Collectively, these results indicate that the beneficial effect of TRH in anaphylactic shock involves central nervous system actions which are mediated peripherally through interaction of sympatho-adrenomedullary catecholamines with beta-adrenoceptive effectors.
TRH Binding (interaction) of in central nervous system associated with anaphylaxis, catecholamine and central nervous system
5) Confidence 0.37 Published 1984 Journal Brain Res. Section Abstract Doc Link 6326950 Disease Relevance 0.40 Pain Relevance 0.29
Thus, these studies provide further in vivo evidence for an acute interaction between TRH and kappa-opiates.
TRH Binding (interaction) of associated with opiate
6) Confidence 0.37 Published 1993 Journal Brain Res. Section Abstract Doc Link 8242390 Disease Relevance 0.13 Pain Relevance 1.00
Barbiturate competition for TRH receptors in mouse brain: neuromodulation of anesthesia.
TRH Binding (competition) of in brain associated with anesthesia
7) Confidence 0.37 Published 1983 Journal Peptides Section Title Doc Link 6312436 Disease Relevance 0 Pain Relevance 0.31
Barbiturate analogues effectively competed for all forebrain and brain stem, but not cortical, TRH receptors, thus implicating these specific receptors in the neuromodulation of barbiturate anesthesia.
TRH Binding (competed) of in brain stem associated with anesthesia
8) Confidence 0.37 Published 1983 Journal Peptides Section Abstract Doc Link 6312436 Disease Relevance 0 Pain Relevance 0.22
Previous studies from this laboratory have indicated that kappa-opiates but not mu-opiates inhibit the binding of [3H][3-MeHis2]-TRH to brain membranes.
TRH Binding (binding) of in brain associated with opiate
9) Confidence 0.36 Published 1993 Journal Brain Res. Section Abstract Doc Link 8242390 Disease Relevance 0.15 Pain Relevance 1.22
TRH-induced antinociception: interaction with the opioid systems?
TRH Binding (interaction) of associated with antinociception, narcan and opioid
10) Confidence 0.36 Published 1987 Journal Gen. Pharmacol. Section Title Doc Link 3032733 Disease Relevance 0 Pain Relevance 0.57
TRH did not modify the binding of [3H]naloxone in mouse brain either in vitro (TRH: 10(-10)-10(-4) M) or ex vivo (TRH: 1-40 mg kg-1 i.p.).
TRH Binding (binding) of in brain associated with narcan
11) Confidence 0.36 Published 1987 Journal Gen. Pharmacol. Section Abstract Doc Link 3032733 Disease Relevance 0 Pain Relevance 0.47
However, several analogues of TRH, including TRH-OH, TRH-Gly-NH2 and other analogues, where each of the three amino acid residues in TRH had been exchanged by a related residue, did not bind to any of the MC receptors tested in this study.
TRH Neg (not) Binding (bind) of
12) Confidence 0.33 Published 1999 Journal Peptides Section Abstract Doc Link 10447100 Disease Relevance 0.18 Pain Relevance 0.07
However, several analogues of TRH, including TRH-OH, TRH-Gly-NH2 and other analogues, where each of the three amino acid residues in TRH had been exchanged by a related residue, did not bind to any of the MC receptors tested in this study.
TRH Binding (bind) of
13) Confidence 0.33 Published 1999 Journal Peptides Section Abstract Doc Link 10447100 Disease Relevance 0.18 Pain Relevance 0.07
We discovered that TRH binds to the human MCI receptor expressed in COS cells and to murine B16 melanoma cells with 5790+/-1010 nM and 6370+/-1260 nM Ki's, respectively.
TRH Binding (binds) of associated with experimental melanoma
14) Confidence 0.32 Published 1999 Journal Peptides Section Abstract Doc Link 10447100 Disease Relevance 0.18 Pain Relevance 0.07
We tested the endogenous tripeptide TRH (thyrotropin releasing hormone) ability to bind to MC (melanocortin) receptor subtypes.
TRH Binding (bind) of
15) Confidence 0.28 Published 1999 Journal Peptides Section Abstract Doc Link 10447100 Disease Relevance 0.16 Pain Relevance 0.07
Barbiturate analogues effectively competed for all forebrain and brain stem, but not cortical, TRH receptors, thus implicating these specific receptors in the neuromodulation of barbiturate anesthesia.
TRH Binding (competed) of in forebrain associated with anesthesia
16) Confidence 0.13 Published 1983 Journal Peptides Section Abstract Doc Link 6312436 Disease Relevance 0 Pain Relevance 0.22

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