INT316484

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.87
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Akt1, Stat3) signal transduction (Akt1, Stat3) nucleus (Akt1, Stat3)
plasma membrane (Akt1, Stat3) transport (Akt1) aging (Akt1)
Akt1 (Mus musculus)
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
inflammatory response 7 84.80 Quite High
Cytokine 22 84.72 Quite High
inflammation 40 50.00 Quite Low
cINOD 2 5.00 Very Low Very Low Very Low
inflammatory mediators 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Antagonist 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 149 98.96 Very High Very High Very High
Lymphatic System Cancer 1 97.00 Very High Very High Very High
Stress 3 96.64 Very High Very High Very High
Genetic Translocation 1 95.64 Very High Very High Very High
INFLAMMATION 47 84.40 Quite High
Apoptosis 11 73.04 Quite High
Colitis 9 5.00 Very Low Very Low Very Low
Colon Cancer 6 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cytoplasmic tyrosine kinases, often in conjunction with Jaks, are likely to mediate Stat3 activation subsequent to many other cancer-initiating, toxic insults, including UV-radiation, stress, and smoke [26,27].
kinases Spec (likely) Positive_regulation (mediate) of Positive_regulation (activation) of Stat3 associated with stress and cancer
1) Confidence 0.01 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.87 Pain Relevance 0.16

General Comments

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