INT316489

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.27
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Stat3, Ccnb1) nucleus (Stat3, Ccnb1) protein complex assembly (Ccnb1)
DNA binding (Stat3) signal transducer activity (Stat3) cell proliferation (Stat3)
Stat3 (Mus musculus)
Ccnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 40 86.92 High High
cytokine 22 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 11 96.64 Very High Very High Very High
Repression 2 95.28 Very High Very High Very High
Death 1 93.36 High High
Inflammatory Bowel Disease 6 87.48 High High
Colon Cancer 6 86.24 High High
Skin Cancer 5 79.12 Quite High
Bladder Cancer 1 76.00 Quite High
Cancer 149 68.00 Quite High
Metastasis 4 59.72 Quite High
INFLAMMATION 47 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, Stat3 promotes proliferation primarily by stimulating transcription of cyclinB1, cdc2, c-myc and cyclinD1 [55,65,66], along with the induction of the immediate early genes c-jun and c-fos [67] and repression of the cell cycle inhibitor p21 [68].
Stat3 Positive_regulation (stimulating) of Transcription (transcription) of cyclinB1 associated with repression
1) Confidence 0.02 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.27 Pain Relevance 0.04

General Comments

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