INT316491

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3) cytoplasm (Socs3)
Socs3 (Mus musculus)
Il11ra1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 22 99.72 Very High Very High Very High
Inflammation 40 97.46 Very High Very High Very High
antagonist 2 91.28 High High
Inflammatory response 7 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 149 99.34 Very High Very High Very High
INFLAMMATION 47 97.46 Very High Very High Very High
Endotoxemia 1 42.12 Quite Low
Sepsis 1 36.76 Quite Low
Lung Cancer 2 19.20 Low Low
Nicotine Addiction 2 18.28 Low Low
Hepatocellular Cancer 5 5.72 Low Low
Apoptosis 11 5.00 Very Low Very Low Very Low
Colitis 9 5.00 Very Low Very Low Very Low
Colon Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings reiterate the critical role played by Socs3 in maintaining an inflammatory, anti-tumourigenic environment characterized by IL12 expression that is converted to a tumour promoting cytokine profile when Socs3 is unable to abate gp130 signaling following engagement of the IL10 family receptor components.
Socs3 Neg (unable) Positive_regulation (abate) of gp130 associated with inflammation, cancer and cytokine
1) Confidence 0.45 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.92 Pain Relevance 0.22

General Comments

This test has worked.

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