INT316493

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.69
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophages 1
epithelium 1
Il6 (Mus musculus)
Il11ra1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 14 99.52 Very High Very High Very High
Inflammation 80 98.60 Very High Very High Very High
cytokine 44 71.88 Quite High
Inflammatory mediators 4 33.52 Quite Low
cINOD 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 94 99.34 Very High Very High Very High
Apoptosis 22 92.56 High High
Colitis 18 91.56 High High
Cancer 298 84.56 Quite High
Targeted Disruption 12 78.48 Quite High
Hepatocellular Cancer 10 75.28 Quite High
Skin Cancer 10 59.40 Quite High
Mucositis 4 11.28 Low Low
Colon Cancer 12 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-proficient epithelium provides a soluble, ligand-binding receptor subunit for IL6 to activate gp130 in IL6R?
IL6 Positive_regulation (activate) of gp130 in epithelium
1) Confidence 0.64 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.89 Pain Relevance 0
Accordingly, transient Stat3 activation by IL6 in wild-type macrophages promotes an inflammatory response, while sustained Stat3 activation by IL6 of gp130Y757F mutant macrophages suppresses the inflammatory gene response through the induction of transcriptional repressors [39,40].
IL6 Positive_regulation (activation) of gp130Y757F in macrophages associated with inflammatory response and inflammation
2) Confidence 0.46 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.80 Pain Relevance 0.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox