INT3165

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Context Info
Confidence 0.65
First Reported 1978
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 16.72
Pain Relevance 5.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LYZ) hydrolase activity, acting on glycosyl bonds (LYZ) extracellular region (LYZ)
Anatomy Link Frequency
monocyte 2
HEL 1
eosinophil 1
egg 1
tear 1
LYZ (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 24 100.00 Very High Very High Very High
Inflammation 344 99.64 Very High Very High Very High
methotrexate 18 99.36 Very High Very High Very High
Chronic pancreatitis 8 99.36 Very High Very High Very High
Somatostatin 2 99.20 Very High Very High Very High
cytokine 238 93.52 High High
rheumatoid arthritis 47 93.44 High High
spastic colon 25 93.40 High High
Pain 35 93.20 High High
Osteoarthritis 41 93.12 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 53 100.00 Very High Very High Very High
Sicca Syndrome 14 100.00 Very High Very High Very High
Urological Neuroanatomy 6 100.00 Very High Very High Very High
Histiocytic Sarcoma 66 99.70 Very High Very High Very High
INFLAMMATION 414 99.64 Very High Very High Very High
Disorders Of The Lacrimal System 48 99.36 Very High Very High Very High
Pancreatitis 8 99.36 Very High Very High Very High
Otitis Media With Effusion 184 98.96 Very High Very High Very High
Bacterial Vaginosis 23 98.68 Very High Very High Very High
Cancer 82 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of carcinoembryonic antigen (CEA) and lysozyme were also determined.
Spec (determined) Gene_expression (expression) of lysozyme
1) Confidence 0.65 Published 1990 Journal Cancer Section Abstract Doc Link 2224768 Disease Relevance 0.93 Pain Relevance 0.29
In addition, lysozyme reactivity was absent in normal pancreas; however, lysozyme was expressed in one case of chronic pancreatitis, 17 cases of primary carcinoma, and three cases of metastatic carcinoma.
Neg (absent) Gene_expression (expressed) of lysozyme in pancreas associated with carcinoma and chronic pancreatitis
2) Confidence 0.65 Published 1990 Journal Cancer Section Abstract Doc Link 2224768 Disease Relevance 1.13 Pain Relevance 0.37
A conjugate was synthesized with an average coupling degree of 2 mol naproxen per 1 mol lysozyme in which the drug was directly coupled to the protein via a peptide bond.
Gene_expression (synthesized) of lysozyme
3) Confidence 0.63 Published 1997 Journal Kidney Int. Section Abstract Doc Link 9407519 Disease Relevance 0.09 Pain Relevance 0.09
Conventional RT-PCR at 30 cycles revealed marked higher expression of HLA-DRA, LYZ, and CD14 transcripts in eEPCs, while CAV1, VE-cadherin, and vWF transcripts were only present in OECs (Figure 3A).
Gene_expression (expression) of LYZ
4) Confidence 0.48 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.07 Pain Relevance 0.04
Serum levels of soluble IL-2 receptor and lysozyme were increased, and a significant uptake was observed by Ga scintigraphy at the nasopharynx and bilateral hilar lymphnodes.
Gene_expression (levels) of lysozyme in nasopharynx
5) Confidence 0.46 Published 2001 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 11280897 Disease Relevance 0.89 Pain Relevance 0.09
N-acetyl-beta-glucosaminidase (EC 3.2.1.30, recommended name beta-N-Acetylglucosaminidase) was found to be a constituent of human cardiac lysosomes. beta-glucuronidase was also found in this tissue, while lysozyme, an enzyme present in leucocyte lysosomes, was not detectable in the heart.
Neg (not) Gene_expression (detectable) of lysozyme in heart
6) Confidence 0.44 Published 1978 Journal Cardiovasc. Res. Section Abstract Doc Link 647716 Disease Relevance 0.37 Pain Relevance 0.15
Immunohistochemical tests were positive in lysozyme, alpha-1-antitrypsin, and alpha-1-antichymotrypsin.
Gene_expression (positive) of lysozyme
7) Confidence 0.40 Published 2001 Journal Arthroscopy Section Abstract Doc Link 11154373 Disease Relevance 0.54 Pain Relevance 0.09
This finding is consistent with the eEPC transcriptome profile that indicated high expression of lysosome enzymes such as lysozyme (LYZ), cathepsins (CTSB, CTSD, CTSH, CTSL1), acid phosphatase (ACP2, ACP5), acid lipase (LIPA), and ?
Gene_expression (expression) of LYZ
8) Confidence 0.37 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0 Pain Relevance 0
This finding is consistent with the eEPC transcriptome profile that indicated high expression of lysosome enzymes such as lysozyme (LYZ), cathepsins (CTSB, CTSD, CTSH, CTSL1), acid phosphatase (ACP2, ACP5), acid lipase (LIPA), and ?
Gene_expression (expression) of lysozyme
9) Confidence 0.32 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0 Pain Relevance 0
In the present study we investigated the ability of N/OFQ, in comparison with the proinflammatory peptide formyl-Met-Leu-Phe (fMLP), to stimulate human neutrophil and monocyte chemotaxis and the release of lysozyme and superoxide anion (O2-) production from neutrophils. fMLP stimulated all the leukocyte functions examined.
Gene_expression (production) of lysozyme in monocyte
10) Confidence 0.27 Published 2005 Journal Peptides Section Abstract Doc Link 15922491 Disease Relevance 0 Pain Relevance 0.28
The granular cells of the current case were positive for neuron-specific enolase (NSE), S-100 protein, GFAP, vimentin, CD 68, lysozyme, and alpha-1-antitrypsin.
Gene_expression (positive) of lysozyme in neuron
11) Confidence 0.25 Published 2008 Journal Neuropathology Section Abstract Doc Link 18466222 Disease Relevance 0.89 Pain Relevance 0.08
Lipopolysaccharide (LPS)-activated human monocytes treated with SKF86002 produced less proIL-1 beta but normal amounts of the noncytokine lysozyme.
Gene_expression (produced) of lysozyme in monocytes
12) Confidence 0.19 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7565623 Disease Relevance 0.35 Pain Relevance 0.28
The key feature suggestive of HS is the strong expression of one or more "histiocytic markers", including CD163, CD68, and lysozyme in the majority of neoplastic cells.
Gene_expression (expression) of lysozyme associated with histiocytic sarcoma
13) Confidence 0.18 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.26 Pain Relevance 0
Our results also showed that fractalkine/CX3CL1, IL-6, IL-8/CXCL8, IL-1Ra, and VEGF levels were inversely correlated with Schirmer test results and lysozyme levels, which measure tear production.
Gene_expression (levels) of lysozyme in tear associated with disorders of the lacrimal system and sicca syndrome
14) Confidence 0.16 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 0.90 Pain Relevance 0.92
They were strongly positive for CD163 (Fig. 4), CD68, lysozyme, NSE, and vimentin.
Gene_expression (positive) of lysozyme
15) Confidence 0.14 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 0.33 Pain Relevance 0
The results show that BV CVF samples are deficient in antimicrobial activity due to lower expression levels of several antimicrobial peptides such as SLPI, defensins, lysozyme and lactoferrin [142-147].
Gene_expression (expression) of lysozyme associated with bacterial vaginosis
16) Confidence 0.14 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 1.06 Pain Relevance 0.13
In general, there was an inverse relationship between the levels of IL-Ra, IL-6, IL-8/CXCL8 and fractalkine/CX3CL1 and the Schirmer test, lysozyme, and TBUT values.
Gene_expression (levels) of lysozyme associated with sicca syndrome and antagonist
17) Confidence 0.12 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 0.50 Pain Relevance 0.26
The analyses included myeloperoxidase (MPO), eosinophil cationic protein (ECP), lysozyme, and albumin and were carried out at the Department of Clinical Chemistry, University Hospital, Uppsala, Sweden.
Spec (analyses) Gene_expression (included) of lysozyme in eosinophil associated with urological neuroanatomy
18) Confidence 0.10 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1314919 Disease Relevance 0.24 Pain Relevance 0.05
In the present study we investigated the ability of N/OFQ, in comparison with the proinflammatory peptide formyl-Met-Leu-Phe (fMLP), to stimulate human neutrophil and monocyte chemotaxis and the release of lysozyme and superoxide anion (O2-) production from neutrophils. fMLP stimulated all the leukocyte functions examined.
Gene_expression (production) of lysozyme in neutrophil
19) Confidence 0.09 Published 2005 Journal Peptides Section Abstract Doc Link 15922491 Disease Relevance 0 Pain Relevance 0.28
In H. pylori our data support a model (Figure 5) whereby DNA damage induces RecA-dependent expression of both a lysozyme-like protein, which stimulates donation of DNA from susceptible H. pylori, and the com T4SS, which increases the import of foreign DNA.
Gene_expression (expression) of lysozyme
20) Confidence 0.08 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2912397 Disease Relevance 0.08 Pain Relevance 0

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