INT316515

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 10.37
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RALBP1) signal transduction (RALBP1) transport (RALBP1)
ATPase activity (RALBP1) intracellular (RALBP1)
Anatomy Link Frequency
lateral 5
meatus 3
trunk 3
nerve 2
urethra 2
RALBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
unmyelinated 27 72.64 Quite High
c fibre 27 71.60 Quite High
chemokine 4 65.20 Quite High
Spinal cord 108 20.52 Low Low
ketamine 27 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress Incontinence 1404 99.96 Very High Very High Very High
Cancer 43 99.64 Very High Very High Very High
Stress 1 97.88 Very High Very High Very High
Apoptosis 4 96.44 Very High Very High Very High
Urinary Dysfunction 27 92.80 High High
Overactive Bladder 108 86.48 High High
Colon Cancer 62 81.56 Quite High
Metastasis 8 78.96 Quite High
Increased Venous Pressure Under Development 27 77.40 Quite High
Recurrence 10 75.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression level of RALBP1 was shown to be increased in many cancer cells by expression array analysis.
Positive_regulation (increased) of RALBP1 associated with cancer
1) Confidence 0.25 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 1.57 Pain Relevance 0.03
Based on these results, both clinical and experimental IES studies (which all utilize a ring electrode) are activating the DNP trunk, not the lateral branches.
Neg (not) Positive_regulation (activating) of DNP in lateral
2) Confidence 0.12 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.29 Pain Relevance 0
The nerves were represented bilaterally as single trunks, and lateral branches of the DNP were later included for further examination of DNP activation in the penile urethra.
Positive_regulation (activation) of DNP in penile urethra associated with stress incontinence
3) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.10 Pain Relevance 0
The selectivity between activation of the DNP and the CSN was dependent on electrode geometry.
Positive_regulation (activation) of DNP
4) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.06 Pain Relevance 0
These results indicate that the DNP is more readily activated by stimulation in the penile urethra while the CSN is more readily activated by stimulation in the membranous urethra, which reflects the proximity of each nerve trunk to the corresponding segment of the urethra.
Positive_regulation (activated) of DNP in nerve trunk associated with stress incontinence
5) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.85 Pain Relevance 0
The ability to activate the DNP selectively without co-activation of the CSN (and vice versa) was calculated for each electrode configuration at the different intraurethral locations (Figure 4).
Positive_regulation (activate) of DNP
6) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.82 Pain Relevance 0
A potential benefit of intraurethral stimulation verses transcutaneous (with external surface electrodes) or percutaneous stimulation of the DNP would be selective activation of urethral as opposed to cutaneous DNP fibers.
Positive_regulation (stimulation) of DNP in external surface
7) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.32 Pain Relevance 0
No electrode geometry exhibited selectivity >1 at 4 cm from the urethral meatus, suggesting that stimulation in the penile bulb will produce co-activation of the CSN and DNP.
Positive_regulation (activation) of DNP in meatus
8) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.06 Pain Relevance 0
AFs generated by stimulation with 12 different electrode configurations (Figure 2A, B) positioned 2 cm from the urethral meatus were compared to determine the electrode configurations that could selectively activate these lateral DNP branches, without activating the DNP trunk and vice versa (Figure 7).
Positive_regulation (activate) of DNP in meatus
9) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.23 Pain Relevance 0
Further, these in vivo observations highlight the importance of selective DNP or CSN activation because the bladder response to activation of these nerves is different for different stimulation frequencies and involves different neural pathways [2].
Positive_regulation (activation) of DNP in neural
10) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.48 Pain Relevance 0
Selective activation of the DNP was best achieved by stimulation in the distal urethra (near the glans) while selective activation of the CSN was best achieved by stimulation in the proximal urethra (near the prostate).
Positive_regulation (activation) of DNP in urethra associated with stress incontinence
11) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.40 Pain Relevance 0
While intraurethral stimulation is an ideal means of activating urethral nerve fibers in the proximal urethra, percutaneous or transcutaneous stimulation of the DNP (or dorsal clitoral nerve) may be achievable at lower thresholds [26].
Positive_regulation (stimulation) of DNP in nerve associated with stress incontinence
12) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.29 Pain Relevance 0
Our results suggest that the range of activation of the lateral branches of the DNP without activation of the DNP trunk varies with electrode geometry.
Neg (without) Positive_regulation (activation) of DNP in trunk
13) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.32 Pain Relevance 0
DNP branch activation depended on electrode geometry
Positive_regulation (activation) of DNP
14) Confidence 0.11 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.31 Pain Relevance 0
This reveals that at ~4 cm (the proximal portion of the penile bulb) neither the DNP nor the CSN can be activated selectively.
Positive_regulation (activated) of DNP in bulb
15) Confidence 0.08 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.40 Pain Relevance 0
For analysis of activation of the lateral branches of the DNP in the penile urethra, the AFs were calculated along 5 lateral DNP branches (Figure 1) in addition to the DNP trunk.
Positive_regulation (activation) of DNP in penile urethra associated with stress incontinence
16) Confidence 0.08 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.23 Pain Relevance 0
Our results suggest that the range of activation of the lateral branches of the DNP without activation of the DNP trunk varies with electrode geometry.
Positive_regulation (activation) of DNP in trunk
17) Confidence 0.08 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.32 Pain Relevance 0
AFs generated by stimulation with 12 different electrode configurations (Figure 2A, B) positioned 2 cm from the urethral meatus were compared to determine the electrode configurations that could selectively activate these lateral DNP branches, without activating the DNP trunk and vice versa (Figure 7).
Neg (without) Positive_regulation (activating) of DNP in meatus
18) Confidence 0.08 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.22 Pain Relevance 0
Additionally, selective activation of the DNP or CSN depends on stimulation location.
Positive_regulation (activation) of DNP
19) Confidence 0.07 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.23 Pain Relevance 0
The selectivity of the ring electrode compared to the 3-ring electrode (Figure 7D) indicated that the ring electrode stimulation threshold would be lower than the 3-ring electrode only in the case of DNP trunk activation.
Positive_regulation (activation) of DNP in trunk
20) Confidence 0.07 Published 2010 Journal BMC Urol Section Body Doc Link PMC2887842 Disease Relevance 0.14 Pain Relevance 0

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