INT31653

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Context Info
Confidence 0.47
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.25
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tead1) DNA binding (Tead1)
Anatomy Link Frequency
SVR 1
Tead1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 107 92.08 High High
epidural 5 90.86 High High
tetrodotoxin 5 86.64 High High
analgesia 3 77.96 Quite High
thoracic epidural anesthesia 9 75.00 Quite High
gABA 5 74.32 Quite High
Glutamate 14 52.72 Quite High
Ventral tegmentum 1 41.04 Quite Low
parabrachial 1 39.56 Quite Low
adenocard 1 24.24 Low Low
Disease Link Frequency Relevance Heat
Pancreatitis 6 99.08 Very High Very High Very High
Stroke 1 93.16 High High
Critical Illness 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: TEA was induced by 15 microl/h bupivacaine, 0.5%.
Positive_regulation (induced) of TEA
1) Confidence 0.47 Published 2009 Journal Anesthesiology Section Body Doc Link 19934868 Disease Relevance 0.10 Pain Relevance 0
This was restored in Pancreatitis + TEA.
Positive_regulation (restored) of TEA
2) Confidence 0.31 Published 2009 Journal Anesthesiology Section Body Doc Link 19934868 Disease Relevance 0.06 Pain Relevance 0
With this model, effects of thoracic epidural anaesthesia (TEA) on mean arterial pressure (MAP), cardiac output (CO), systemic vascular resistance (SVR), stroke volume (SV), heart rate (HR), central venous pressure (CVP), left ventricular end-diastolic pressure (LVEDP) and maximal increase of pressure in the left ventricle (max dp/dt) were studied in six groups of animals: 1) In conscious animals (n = 10) MAP, CO, SV and HR decreased significantly by 12%, 25%, 10% and 16%, respectively, while SVR increased significantly by 20% during TEA; 2) In chloralose-anaesthetized animals (n = 7) the reduction in CO during TEA was less pronounced and there were no significant changes in SV or SVR; 3) In conscious animals (n = 6) LVEDP, CVP and max dp/dt decreased significantly during TEA; 4) Hexamethonium, when administered to pharmacologically vagotomized conscious animals during TEA (n = 8), induced a significant decrease in SVR (23%) but no change in HR; 5) Changes in haemodynamics after cardiac adrenoceptor blockade with metoprolol, in conscious animals (n = 12), did not differ significantly from those seen during TEA, except for an unchanged SV after metoprolol; 6) 50 microliters of bupivacaine (5 mg/ml) when given i.v. to conscious animals (n = 8) did not affect CO, SV, HR or TPR significantly, while MAP increased slightly but significantly.
Positive_regulation (increased) of TEA in SVR associated with stroke and epidural
3) Confidence 0.28 Published 1988 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 2896422 Disease Relevance 0.09 Pain Relevance 0.27
suppression of EPSPs (see Figure 4(b1)), and a D1 receptor-dependent activation of a TEA-sensitive K+ conductance
Positive_regulation (activation) of TEA-sensitive
4) Confidence 0.01 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2519792 Disease Relevance 0 Pain Relevance 0.39

General Comments

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