INT316547

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
superior 1
Sst1 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 50 99.38 Very High Very High Very High
dexamethasone 2 97.28 Very High Very High Very High
agonist 51 94.76 High High
Dopamine 46 56.36 Quite High
antagonist 8 5.12 Low Low
withdrawal 9 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Onset of action 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 68 92.52 High High
Acth-secreting Pituitary Adenoma 14 91.92 High High
Adenoma 16 86.76 High High
Acromegaly 35 81.68 Quite High
Pituitary Cancer 28 71.12 Quite High
Cancer 73 66.24 Quite High
Prolactinoma 48 50.00 Quite Low
Pituitary Acth Hypersecretion 3 50.00 Quite Low
Nelson Syndrome 3 43.28 Quite Low
Diabetes Mellitus 12 28.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, octreotide (that binds preferentially sst2 but only modestly sst5), but not pasireotide (a universal ligand with high binding affinity for sst1, sst2, sst3, and sst5), lost most of its ACTH-inhibiting potential with glucocorticoid pretreatment53 or in patients with CD in vivo.54 Two studies55,56 investigated the effects of SS analogs in human corticotroph adenoma tissues; a superior ACTH inhibition by pasireotide as compared with octreotide55 and a dissociation in some adenomas between the antisecretory and antiproliferative effects of pasireotide56 were reported similar to what is observed in acromegaly.57,58

Efficacy in clinical studies

sst1 Binding (binds) of in superior associated with adenoma, acromegaly, acth-secreting pituitary adenoma and somatostatin
1) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.32 Pain Relevance 0.64
The novel multi-receptor tageted somatostatin analogue pasireotide has high affinity for sst1, 2, 3 and sst5.
sst1 Binding (affinity) of associated with somatostatin
2) Confidence 0.07 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 0.52 Pain Relevance 0.09

General Comments

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