INT316622

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.27
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dao) peroxisome (Dao)
Anatomy Link Frequency
brainstem 1
cerebellum 1
Dao (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 54 98.88 Very High Very High Very High
nMDA receptor 87 98.44 Very High Very High Very High
medulla 15 98.04 Very High Very High Very High
Glutamate 72 55.36 Quite High
Nucleus accumbens 15 42.20 Quite Low
Hippocampus 30 41.32 Quite Low
Pain 24 5.00 Very Low Very Low Very Low
antagonist 18 5.00 Very Low Very Low Very Low
Glutamate receptor 15 5.00 Very Low Very Low Very Low
ASIC 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 39 95.28 Very High Very High Very High
Schizophrenia 66 86.56 High High
Psychosis 9 66.80 Quite High
Disease 9 60.08 Quite High
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Pain 21 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors

D-amino acid oxidase (DAAO) is a flavoenzyme that degrades D-amino acids through the process of oxidative deamination.

Gene_expression (oxidase) of D-Amino Acid
1) Confidence 0.52 Published 2010 Journal The Open Medicinal Chemistry Journal Section Title Doc Link PMC2905773 Disease Relevance 0.51 Pain Relevance 0.07
DAAO regulation of D-amino acid levels has been associated with several physiological processes ranging from hormone secretion to synaptic transmission and cognition.
Gene_expression (levels) of D-amino acid associated with cognitive disorder
2) Confidence 0.46 Published 2010 Journal The Open Medicinal Chemistry Journal Section Abstract Doc Link PMC2905773 Disease Relevance 0.24 Pain Relevance 0.05
The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors

D-amino acid oxidase (DAAO) is a flavoenzyme that degrades D-amino acids through the process of oxidative deamination.

Gene_expression (oxidase) of D-amino acid
3) Confidence 0.46 Published 2010 Journal The Open Medicinal Chemistry Journal Section Title Doc Link PMC2905773 Disease Relevance 0.51 Pain Relevance 0.07
Second, D-serine levels increase during postnatal development and start to decrease when DAAO expression begins, 2 wk after postnatal development of the brainstem and cerebellum (Hashimoto et al., 1995; Horiike et al., 2001; Wang and Zhu, 2003).
Gene_expression (expression) of DAAO in cerebellum associated with medulla
4) Confidence 0.35 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0 Pain Relevance 0.48
Moreover, extracellular application of NMDA resulted in a reduced response in PPNs of the MNTB when DAAO is present, supporting D-serine as co-agonist of NMDA receptors.
Gene_expression (present) of DAAO associated with nmda receptor and agonist
5) Confidence 0.30 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0 Pain Relevance 0.41
Second, D-serine levels increase during postnatal development and start to decrease when DAAO expression begins, 2 wk after postnatal development of the brainstem and cerebellum (Hashimoto et al., 1995; Horiike et al., 2001; Wang and Zhu, 2003).
Gene_expression (expression) of DAAO in brainstem associated with medulla
6) Confidence 0.12 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0 Pain Relevance 0.48

General Comments

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