INT316647

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.68
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ryr1, Qdpr) cytosol (Qdpr) mitochondrion (Qdpr)
transport (Ryr1) oxidoreductase activity (Qdpr) plasma membrane (Ryr1)
Ryr1 (Mus musculus)
Qdpr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 10 27.76 Quite Low
addiction 22 5.00 Very Low Very Low Very Low
halothane 4 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 30 100.00 Very High Very High Very High
Contracture 4 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the evidence that RYR1 has retrograde effects on DHPR function, and that this retrograde signal is affected by RYR1 conformation as described above, the question naturally arises of whether malignant hyperthermia (MH)-causing mutations in RYR1 affect DHPR function.
RYR1 Regulation (effects) of DHPR associated with malignant hyperthermia
1) Confidence 0.19 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.31 Pain Relevance 0
Because the DHPR and RYR1 are functionally coupled, mutations in RYR1 that are linked to malignant hyperthermia (MH) may affect DHPR activity.
RYR1 Spec (may) Regulation (affect) of DHPR associated with malignant hyperthermia
2) Confidence 0.19 Published 2010 Journal The Journal of General Physiology Section Abstract Doc Link PMC2888063 Disease Relevance 0.37 Pain Relevance 0

General Comments

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