INT316690

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.75
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Myd88) signal transduction (Myd88) plasma membrane (Myd88)
intracellular (Myd88) protein complex (Myd88) cytoplasm (Myd88)
Anatomy Link Frequency
endothelial cells 1
Myd88 (Mus musculus)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 84 95.40 Very High Very High Very High
Inflammatory response 6 95.16 Very High Very High Very High
cytokine 27 81.28 Quite High
Arthritis 4 75.56 Quite High
Hyperalgesia 1 70.96 Quite High
Pain 2 58.36 Quite High
chemokine 5 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 90 95.40 Very High Very High Very High
Crystal Associated Disease 75 90.36 High High
Systemic Lupus Erythematosus 61 86.28 High High
Peritonitis 7 85.96 High High
Hyperalgesia 1 70.96 Quite High
Autoimmune Disease 23 69.04 Quite High
Targeted Disruption 5 62.52 Quite High
Pain 2 58.36 Quite High
Renal Disease 3 51.76 Quite High
Arthritis 5 41.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As both IL-1RI and MyD88 are essential for signal transduction on IL-1 binding, these results showed that nonhematopoieitic cells, most probably endothelial cells, are necessary to develop fully the inflammatory response to IL-1?.


MyD88 Binding (binding) of IL-1 in endothelial cells associated with inflammatory response
1) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 1.36 Pain Relevance 0.60
The results of this mimic showed an inhibition of MyD88 and IL-1RI interaction by ablating phosphorylation of MAP kinases [86].
MyD88 Binding (interaction) of IL-1RI
2) Confidence 0.00 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.40 Pain Relevance 0.06

General Comments

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