INT3167

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Context Info
Confidence 0.48
First Reported 1978
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 48
Total Number 48
Disease Relevance 23.26
Pain Relevance 26.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)
Anatomy Link Frequency
plasma 3
smooth muscle 2
skin 2
lung 2
ileum 1
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 613 100.00 Very High Very High Very High
b2 receptor 77 100.00 Very High Very High Very High
substance P 16 100.00 Very High Very High Very High
Serotonin 9 100.00 Very High Very High Very High
Enkephalin 9 100.00 Very High Very High Very High
Neuropeptide 8 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
narcan 2 100.00 Very High Very High Very High
Cholecystokinin 1 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 109 100.00 Very High Very High Very High
Asthma 85 100.00 Very High Very High Very High
Weight Loss 44 100.00 Very High Very High Very High
Pressure And Volume Under Development 89 99.80 Very High Very High Very High
Glioma 60 99.72 Very High Very High Very High
INFLAMMATION 127 99.52 Very High Very High Very High
Natriuresis 3 99.46 Very High Very High Very High
Hereditary Angioedema 284 99.34 Very High Very High Very High
Pain 103 99.30 Very High Very High Very High
Cough 12 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A study of the interaction of practolol with acetylcholine, histamine, serotonin and bradykinin in the guinea-pig, and with bean-sprout juice in the mouse.
bradykinin Binding (interaction) of associated with bradykinin and serotonin
1) Confidence 0.48 Published 1978 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 648039 Disease Relevance 0.29 Pain Relevance 0.49
Aspirin does not influence the receptor ability to transduce bradykinin binding into activation of G-proteins and phospholipase C.
bradykinin Binding (binding) of associated with aspirin and bradykinin
2) Confidence 0.38 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18355801 Disease Relevance 0.24 Pain Relevance 1.07
Cells most likely to respond to bradykinin received both A delta- and C-fiber renal inputs and/or were located in lamina V of the spinal gray matter.
bradykinin Binding (respond) of in gray matter associated with c fibre and bradykinin
3) Confidence 0.37 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3202232 Disease Relevance 0.07 Pain Relevance 0.47
These results suggest that the beta-turn at the C-terminus of bradykinin is an important secondary structural feature for receptor recognition and binding.
bradykinin Binding (binding) of associated with bradykinin
4) Confidence 0.36 Published 1994 Journal Biopolymers Section Abstract Doc Link 8003621 Disease Relevance 0.35 Pain Relevance 0.41
The bradykinin B2 receptor (BDKRB2) has high affinity for the intact kinins, which mediate a wide spectrum of biological effects, including pain, inflammation, vasodilation, and smooth muscle contraction and relaxation.
bradykinin Binding (affinity) of in smooth muscle associated with pain, inflammation, b2 receptor and increased venous pressure under development
5) Confidence 0.36 Published 1994 Journal Genomics Section Abstract Doc Link 7835885 Disease Relevance 0.29 Pain Relevance 0.34
Angiotensins I and III, bradykinin, neurotensin, physalaemin, substance P octapeptide, insulin, and Leu- and Met-enkephalin show little or no binding.
bradykinin Binding (binding) of associated with enkephalin, bradykinin and substance p
6) Confidence 0.36 Published 1982 Journal Biochemistry Section Abstract Doc Link 6180761 Disease Relevance 0 Pain Relevance 0.33
In models of inflammatory pain, intraplantar administration of IL-4 peptide reduces pain caused by subsequent intraplantar injection of carageeninin, bradykinin or TNF?
bradykinin Binding (injection) of associated with pain, eae and bradykinin
7) Confidence 0.36 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.22 Pain Relevance 1.32
Characterization of bradykinin receptors in human lung fibroblasts using the binding of 3[H][Des-Arg10,Leu9]kallidin and [3H]NPC17731.
bradykinin Binding (Characterization) of in lung associated with bradykinin
8) Confidence 0.36 Published 1998 Journal Life Sci. Section Title Doc Link 9651119 Disease Relevance 0.19 Pain Relevance 0.69
The interactions between the positively charged neuropeptides substance P (SP), bradykinin (BK), and zwitterionic Met-enkephalin (ME) neuropeptides, and negatively charged SDS and zwitterionic lysophosphatidylcholine (LPC) membrane model systems, have been investigated using one- and two-dimensional nmr experiments.
bradykinin Binding (interactions) of associated with neuropeptide, enkephalin, bradykinin and substance p
9) Confidence 0.36 Published 1992 Journal Biopolymers Section Abstract Doc Link 1377514 Disease Relevance 0 Pain Relevance 0.53
This result could not be predicted on the basis of inhibition of bradykinin binding to its guinea-pig ileum receptor or to previous studies of bradykinin-induced pain production in animal models.
bradykinin Binding (binding) of in ileum associated with pain and bradykinin
10) Confidence 0.36 Published 1992 Journal Arch. Dermatol. Res. Section Abstract Doc Link 1554240 Disease Relevance 0.54 Pain Relevance 1.17
The interactions of practolol with acetylcholine, histamine, serotonin and bradykinin were studied on the trachea and lung of the guinea-pig, an animal whose sensitivity to bronchoactive endogens is known to be similar to that of human asthmatic bronchi. 2.
bradykinin Binding (interactions) of in trachea associated with occupational lung diseases, bradykinin and serotonin
11) Confidence 0.31 Published 1978 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 648039 Disease Relevance 0.16 Pain Relevance 0.38
P2Y purinergic receptors are also highly expressed at the glio-vascular interface, suggesting that an interaction between bradykinin and P2Y purinergic receptors could play a role in the interaction of glioma cells with the vasculature [45].
bradykinin Binding (interaction) of in vasculature associated with bradykinin and glioma
12) Confidence 0.30 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.90 Pain Relevance 0.43
Significant quantities of ATP may be released in association with these same events, which therefore represent other settings in which interaction between bradykinin and ATP-mediated signaling may be important [47].
bradykinin Binding (interaction) of associated with bradykinin
13) Confidence 0.30 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 1.05 Pain Relevance 0.53
Measurement of individual bradykinin and kallidin peptides and their metabolites gives important information about the operation of the plasma and tissue KKS and their role in physiology and disease states.
bradykinin Binding (Measurement) of in plasma associated with disease and bradykinin
14) Confidence 0.30 Published 2001 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 11903316 Disease Relevance 0.32 Pain Relevance 0.34
The Rat 13 cells display two binding sites for bradykinin: a moderate number (52,000) of high affinity sites (Kd = 4.9 nM) co-exist with a much smaller number (1100) of very high-affinity sites (Kd = 2.7 pM).
bradykinin Binding (binding) of associated with bradykinin
15) Confidence 0.30 Published 1989 Journal J. Cell. Sci. Section Abstract Doc Link 2561128 Disease Relevance 0.09 Pain Relevance 0.33
Interaction between bradykinin and purinergic signaling may therefore be involved in the regulation of glial tumor cells.


bradykinin Binding (Interaction) of associated with bradykinin and glioma
16) Confidence 0.29 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC2955562 Disease Relevance 0.53 Pain Relevance 0.28
The effect of aspirin on bradykinin binding to cell-surface receptor and on signal transduction were studied in CHO-K1 cells, stably expressing the human B2 receptor.
bradykinin Binding (binding) of associated with aspirin, b2 receptor and bradykinin
17) Confidence 0.29 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18355801 Disease Relevance 0.36 Pain Relevance 0.75
Aspirin inhibits human bradykinin B2 receptor ligand binding function.
bradykinin Binding (binding) of associated with aspirin and b2 receptor
18) Confidence 0.28 Published 2008 Journal Biochem. Pharmacol. Section Title Doc Link 18355801 Disease Relevance 0.35 Pain Relevance 1.00
Bradykinin and ATP-mediated signaling may interact via multiple pathways.
Bradykinin Binding (interact) of associated with bradykinin
19) Confidence 0.27 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.69 Pain Relevance 0.39
Bradykinin was bound to cells of all sizes, ranging from 40 to 2000 microns2 with a maximum of 200-300 microns2.
Bradykinin Binding (bound) of associated with bradykinin
20) Confidence 0.25 Published 1996 Journal Neuroscience Section Abstract Doc Link 8938754 Disease Relevance 0.24 Pain Relevance 0.84

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