INT316708

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 11.52
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 8
joint 7
ankle joints 1
Pgia1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 819 100.00 Very High Very High Very High
Multiple sclerosis 81 99.16 Very High Very High Very High
imagery 180 98.52 Very High Very High Very High
Inflammation 216 94.64 High High
Central nervous system 18 94.20 High High
chemokine 9 79.44 Quite High
cytokine 18 79.04 Quite High
rheumatoid arthritis 225 77.44 Quite High
agonist 9 71.36 Quite High
anesthesia 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 1035 100.00 Very High Very High Very High
Severe Combined Immunodeficiency 504 99.84 Very High Very High Very High
Multiple Sclerosis 108 99.16 Very High Very High Very High
Synovitis 9 97.52 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 18 96.52 Very High Very High Very High
Pressure And Volume Under Development 63 95.16 Very High Very High Very High
INFLAMMATION 207 94.64 High High
Disease 162 92.00 High High
Rheumatoid Arthritis 225 77.44 Quite High
Autoimmune Disease 63 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As we demonstrate in this study, it is easy to identify Gr-1hi cells, in contrast to T cells, in both synovial tissue and fluid samples of inflamed ankle joints of SCID mice with adoptively transferred PGIA.
Positive_regulation (transferred) of Gene_expression (transferred) of PGIA in T cells associated with severe combined immunodeficiency and arthritis
1) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.62 Pain Relevance 0.52
However, in the adoptively transferred model of PGIA, we could hardly detect any T cells within the synovial tissue of the joints of SCID mice by TPM imaging either before or after arthritis development.
Positive_regulation (transferred) of Gene_expression (transferred) of PGIA in T cells associated with severe combined immunodeficiency, imagery and arthritis
2) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.36 Pain Relevance 0.59
In adoptively transferred PGIA, we found that FTY720 treatment of SCID mice, transferred with arthritic donor lymphocytes, effectively reduced T-cell presence in both the circulation and synovial fluid but did not inhibit or delay the transfer of arthritis.
Positive_regulation (transferred) of Gene_expression (transferred) of PGIA in T-cell associated with severe combined immunodeficiency and arthritis
3) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.69 Pain Relevance 0.48
To this end, we chose to administer oral treatment with the S1P receptor modulator FTY720 [20] to the SCID mice during the adoptive transfer of PGIA.
Positive_regulation (transfer) of Gene_expression (transfer) of PGIA associated with severe combined immunodeficiency and arthritis
4) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.80 Pain Relevance 0.26
Although neither immune serum nor T cells or B cells (from arthritic animals) appear to be capable of transferring PGIA to SCID mice when injected alone [12,13], mild and transient synovitis is observed after co-injection of immune serum and T cells (but not B cells), and this mild inflammation can even be extended by repeated administration of immune serum ([27] and our unpublished data).
Positive_regulation (transferring) of Gene_expression (transferring) of PGIA in T cells associated with inflammation, synovitis, severe combined immunodeficiency and arthritis
5) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.16 Pain Relevance 0.33
In vivo and ex vivo imaging methods reveal poor T-cell migration into the joints during the adoptive transfer of PGIA to SCID mice
Positive_regulation (transfer) of Gene_expression (transfer) of PGIA in joints associated with severe combined immunodeficiency, imagery and arthritis
6) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.48 Pain Relevance 0.13
First, using in vivo two-photon microscopy (TPM), we monitored the migration of fluorescence-labeled T cells into the ankle joints and joint-draining lymph nodes (JDLNs) of syngeneic severe combined immunodeficient (SCID) mice during the course of the adoptive transfer of PGIA.
Positive_regulation (transfer) of Gene_expression (transfer) of PGIA in joint associated with severe combined immunodeficiency and arthritis
7) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.44 Pain Relevance 0.61
This is a distinct possibility as Wang and colleagues [40] could identify numerous CD4+ cells in the inflamed joint tissue of CIA rats by IHC, whereas we could detect essentially none in adoptively transferred PGIA by means of a similar method.
Positive_regulation (transferred) of Neg (none) Gene_expression (transferred) of PGIA in joint associated with arthritis
8) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.53 Pain Relevance 0.66
First, using in vivo two-photon microscopy (TPM), we monitored the migration of fluorescence-labeled T cells into the ankle joints and joint-draining lymph nodes (JDLNs) of syngeneic severe combined immunodeficient (SCID) mice during the course of the adoptive transfer of PGIA.
Positive_regulation (transfer) of in ankle joints Gene_expression (transfer) of PGIA in joint associated with severe combined immunodeficiency and arthritis
9) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.44 Pain Relevance 0.61

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