INT316764

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.53
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90b1) protein folding (Hsp90b1) cytosol (Hsp90b1)
endoplasmic reticulum (Hsp90b1) RNA binding (Hsp90b1) response to stress (Hsp90b1)
Anatomy Link Frequency
muscle fibers 1
mesoderm 1
Hsp90b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 6 98.20 Very High Very High Very High
Inflammation 70 87.08 High High
cytokine 4 82.20 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 58 98.20 Very High Very High Very High
Stress 56 95.60 Very High Very High Very High
Myositis 84 90.60 High High
Death 6 76.04 Quite High
Disease 12 48.64 Quite Low
Muscle Disease 2 39.24 Quite Low
Muscular Dystrophy 2 32.68 Quite Low
Targeted Disruption 2 32.04 Quite Low
Apoptosis 2 25.64 Quite Low
Autoimmune Disease 2 15.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Grp94 is required for mesoderm induction and muscle cell differentiation [14], in so far as it redistributes after Fyn-mediated tyrosine phosphorylation in the secretory pathway [15], where it is probably involved in processing of insulin-like growth factor II [16], and, eventually, localizes at the cell surface, where it participates in myotube formation [13].
Localization (localizes) of Grp94 in mesoderm
1) Confidence 0.53 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.58 Pain Relevance 0.03
Interestingly, a single LPS injection increased significantly Grp75 protein levels in skeletal muscle fibers, in the absence of both Grp94 [24] and MHC-I upregulation (present manuscript), proving that systemic inflammatory stimuli do raise the expression of this antioxidant stress-protein in muscle fibers.
Localization (upregulation) of Grp94 in muscle fibers associated with stress and inflammatory stimuli
2) Confidence 0.53 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.95 Pain Relevance 0.25

General Comments

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