INT316768

Context Info Confidence 0.11 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.95 Pain Relevance 0.25

Anatomy Link Frequency muscle fibers 2 H2-K1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory stimuli 3 98.20 Inflammation 35 87.72 cytokine 2 82.84 anesthesia 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 29 98.20 Stress 28 95.60 Myositis 42 80.84 Muscle Disease 1 39.88 Muscular Dystrophy 1 33.32 Apoptosis 1 26.28 Aging 1 10.20 Disease 6 5.00 Muscle Weakness 4 5.00 Sprains And Strains 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, a single LPS injection increased significantly Grp75 protein levels in skeletal muscle fibers, in the absence of both Grp94 [24] and MHC-I upregulation (present manuscript), proving that systemic inflammatory stimuli do raise the expression of this antioxidant stress-protein in muscle fibers.

Regulation (absence) of Localization (upregulation) of MHC-I in muscle fibers associated with stress and inflammatory stimuli

1) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.95 Pain Relevance 0.25

General Comments

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