INT316778

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 7.20
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ENPP1) extracellular space (ENPP1) small molecule metabolic process (ENPP1)
plasma membrane (ENPP1)
Anatomy Link Frequency
cartilage 4
ENPP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 515 99.92 Very High Very High Very High
adenocard 10 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 525 99.92 Very High Very High Very High
Calcification 420 96.08 Very High Very High Very High
Osteogenic Sarcomas 25 83.16 Quite High
Amputation 15 82.08 Quite High
Frailty 15 79.96 Quite High
Chondrocalcinosis 30 67.24 Quite High
Disease 50 5.00 Very Low Very Low Very Low
Ankylosis 10 5.00 Very Low Very Low Very Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we found that the expression of several genes implicated in the biomineralization biological process including ENPP1 and ANKH was upregulated in OA meniscal cells.
Positive_regulation (upregulated) of Gene_expression (expression) of ENPP1 associated with osteoarthritis
1) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.40 Pain Relevance 0.43
Elevated gene expression of ANKH and ENPP1 causes crystal deposition in cartilage [25,45].
Positive_regulation (causes) of Gene_expression (expression) of ENPP1 in cartilage
2) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.27 Pain Relevance 0.37
Elevated gene expression of ANKH and ENPP1 causes crystal deposition in cartilage [25,45].
Positive_regulation (Elevated) of Gene_expression (expression) of ENPP1 in cartilage
3) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.27 Pain Relevance 0.37
Both microarray and real-time RT-PCR analyses indicated that the expression of ENPP1 and ANKH was upregulated in OA meniscal cells (Table 2).
Positive_regulation (upregulated) of Gene_expression (expression) of ENPP1 associated with osteoarthritis
4) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.35 Pain Relevance 0.32
The expression of several genes involved in biomineralization including ENPP1 and ANKH was upregulated in OA meniscal cells.
Positive_regulation (upregulated) of Gene_expression (expression) of ENPP1 associated with osteoarthritis
5) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888206 Disease Relevance 1.90 Pain Relevance 0.48

General Comments

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