INT316791

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB1) signal transduction (Traf1) Golgi apparatus (HLA-DRB1)
endoplasmic reticulum (HLA-DRB1) plasma membrane (HLA-DRB1) cytoplasm (Traf1)
HLA-DRB1 (Homo sapiens)
Traf1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 134 99.76 Very High Very High Very High
Inflammation 24 71.96 Quite High
Arthritis 8 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 138 99.76 Very High Very High Very High
Disease 48 96.08 Very High Very High Very High
INFLAMMATION 18 71.96 Quite High
Musculoskeletal Disease 12 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Autoimmune Disease 6 5.00 Very Low Very Low Very Low
Genetic Predisposition To Disease 4 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 4 5.00 Very Low Very Low Very Low
Systemic Lupus Erythematosus 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association of HLA-DRB1 SE, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 with RA severity
HLA-DRB1 Binding (Association) of TRAF1/C5 associated with rheumatoid arthritis
1) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888207 Disease Relevance 0.33 Pain Relevance 0.08
The present study supports an association between HLA-DRB1 SE alleles, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 with susceptibility to autoantibody-positive RA, but only the TRAF1/C5 locus was associated with disease severity in this cohort, although this would no longer remain significant after correction for multiple comparisons.
HLA-DRB1 Binding (association) of TRAF1/C5 associated with rheumatoid arthritis and disease
2) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888207 Disease Relevance 0.63 Pain Relevance 0.19

General Comments

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