INT316816

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sparc, Col7a1) proteinaceous extracellular matrix (Sparc, Col7a1) intracellular (Sparc)
cytoplasm (Sparc) extracellular space (Sparc) signal transduction (Sparc)
Anatomy Link Frequency
fibroblasts 2
Sparc (Mus musculus)
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 33 50.00 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 53 78.08 Quite High
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Systemic Sclerosis 10 5.00 Very Low Very Low Very Low
Pulmonary Fibrosis 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Keloid Scars 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Pulmonary Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study whether inhibition of SPARC induced a reduction of collagen in the fibroblasts from constitutively active Tgfbr1 mice, we transfected SPARC siRNA into cultured fibroblasts obtained from TBR1CA; Cre-ER mice injected with 4-OHT.
Spec (13611) Negative_regulation (inhibition) of SPARC in fibroblasts Spec (whether) Negative_regulation (reduction) of collagen
1) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.08 Pain Relevance 0

General Comments

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