INT316821

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a2, Col3a1) extracellular region (Col1a2, Col3a1) proteinaceous extracellular matrix (Col1a2, Col3a1)
protein binding, bridging (Col1a2)
Anatomy Link Frequency
lung 1
Col1a2 (Mus musculus)
Col3a1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 33 50.00 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 53 71.00 Quite High
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Systemic Sclerosis 10 5.00 Very Low Very Low Very Low
Pulmonary Fibrosis 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Keloid Scars 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Pulmonary Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in Ctgf siRNA or SPARC siRNA treated mice skin that also received bleomycin injection, the expression of the Col1a2 and Col3a1 appeared to be normal in skin tissues (Figure 5A, P = 0.025 and 0.003 for each gene in Ctgf siRNA treatment, and P = 0.031 and 0.010 in SPARC siRNA treatment), and were significantly improved in lung tissues (about 2.7-fold reduction for Col1a2 and 1.9-fold reduction for Col3a1, compared to bleomyin-injected mice without siRNA treatment, P < 0.05 for both) (Figure 5B).
Col1a2 Negative_regulation (reduction) of Col3a1 in lung
1) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.07 Pain Relevance 0

General Comments

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