INT316824

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sparc, Col7a1) proteinaceous extracellular matrix (Sparc, Col7a1) intracellular (Sparc)
cytoplasm (Sparc) extracellular space (Sparc) signal transduction (Sparc)
Anatomy Link Frequency
fibroblast 3
Sparc (Mus musculus)
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 33 68.48 Quite High
chemokine 1 65.20 Quite High
Inflammatory response 1 41.44 Quite Low
Inflammatory marker 1 35.88 Quite Low
Inflammation 9 28.48 Quite Low
corticosteroid 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.28 Very High Very High Very High
Fibrosis 53 96.68 Very High Very High Very High
Sprains And Strains 1 87.36 High High
Systemic Sclerosis 10 43.52 Quite Low
INFLAMMATION 11 41.08 Quite Low
Pulmonary Fibrosis 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Keloid Scars 2 5.00 Very Low Very Low Very Low
Pulmonary Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies described here consistently demonstrated that inhibition of SPARC with siRNA significantly reduced collagen expression in both in vitro transgenic Tgfbr1 fibroblast model and in vivo bleomycin-induced fibrotic mouse models.
Negative_regulation (inhibition) of SPARC in fibroblast Negative_regulation (reduced) of Gene_expression (expression) of collagen in fibroblast associated with fibrosis and targeted disruption
1) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.82 Pain Relevance 0.09

General Comments

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