INT316852

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA1) plasma membrane (ITGA1)
Anatomy Link Frequency
chondrocytes 1
ITGA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 1 97.60 Very High Very High Very High
Osteoarthritis 21 96.56 Very High Very High Very High
Inflammation 11 66.32 Quite High
cytokine 6 65.28 Quite High
Inflammatory mediators 3 61.48 Quite High
metalloproteinase 6 60.24 Quite High
Arthritis 27 50.00 Quite Low
rheumatoid arthritis 40 5.00 Very Low Very Low Very Low
Bioavailability 9 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 17 97.60 Very High Very High Very High
Osteoarthritis 21 96.56 Very High Very High Very High
Apoptosis 17 52.16 Quite High
Arthritis 33 50.00 Quite Low
Arthropathy 4 27.28 Quite Low
Rheumatic Diseases 3 11.00 Low Low
Rheumatoid Arthritis 40 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Osteoporosis 7 5.00 Very Low Very Low Very Low
Hypercalcemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This resulted in the reduced accumulation of phosphorylated c-Jun and activation protein-1 DNA binding activity, and of activation protein-1-mediated inflammatory responses in OA chondrocytes.
Positive_regulation (accumulation) of activation protein-1 in chondrocytes associated with inflammatory response and osteoarthritis
1) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.44 Pain Relevance 0.31

General Comments

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