INT316913

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.88
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Utrn) nucleus (Utrn) cytoplasm (Utrn)
Anatomy Link Frequency
cardiac muscle 2
Utrn (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 59 92.60 High High
metalloproteinase 1 77.64 Quite High
Calcium channel 2 24.12 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 1 99.92 Very High Very High Very High
Necrosis 4 96.76 Very High Very High Very High
Cardiomyopathy 63 96.32 Very High Very High Very High
Muscular Dystrophy 151 93.12 High High
Fibrosis 71 92.60 High High
Disease 5 79.12 Quite High
Dilated Cardiomyopathy 18 46.56 Quite Low
Death 11 8.00 Low Low
Body Weight 23 5.00 Very Low Very Low Very Low
Duchenne Muscular Dystrophy 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relatively mild phenotype and near normal life span of the mdx mouse has prompted the generation of double mutants such as the mdx/utrophin and the mdx/MyoD mice, both of which have a far more severe skeletal and cardiac muscle phenotype to model the development of cardiomyopathy.
Positive_regulation (generation) of Positive_regulation (/) of utrophin in cardiac muscle associated with cardiomyopathy
1) Confidence 0.49 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 1.43 Pain Relevance 0
L- arginine reduces sarcolemmal injury by inducing up-regulation of utrophin and ?
Positive_regulation (inducing) of Positive_regulation (up-regulation) of utrophin associated with injury
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0.45 Pain Relevance 0.16

General Comments

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