INT316929

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde5a, Ephb1) endosome (Ephb1) cytosol (Pde5a)
plasma membrane (Ephb1) cytoplasm (Ephb1)
Anatomy Link Frequency
synapses 1
Pde5a (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 147 97.32 Very High Very High Very High
long-term potentiation 13 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 76 96.44 Very High Very High Very High
Shock 20 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Aids-related Complex 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, these findings suggest that NMDAR-driven synaptic plasticity, NO-cGMP-PKG signaling, and ERK/MAPK activation regulate the expression of pre- and postsynaptically-localized proteins at LA synapses following fear conditioning, but in unique ways.
cGMP-PKG Regulation (regulate) of ERK in synapses associated with anxiety disorder and amygdala
1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.17 Pain Relevance 0.27

General Comments

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