INT316940

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.41
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Rhoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 26 97.74 Very High Very High Very High
amygdala 294 91.96 High High
Glutamate 6 83.12 Quite High
Hippocampus 6 41.76 Quite Low
antagonist 12 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 152 84.48 Quite High
Shock 40 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low
Aids-related Complex 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, studies employing hippocampal cultures found that LTP-induced alterations in pre- (synapsin and synaptophysin) and postsynaptic (GluR1) proteins were associated with increases in the phosphorylation of the actin cytoskeleton regulators VASP and RhoA [26], and impaired following application of an actin polymerization inhibitor [24].
Positive_regulation (increases) of Phosphorylation (phosphorylation) of RhoA associated with long-term potentiation
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.20 Pain Relevance 0.24
In vitro studies in hippocampal area CA1 have shown that LTP-induced alterations in pre- and postsynaptic proteins are blocked by inhibitors of actin polymerization [24] and associated with increases in the phosphorylation of the actin cytoskeleton regulators VASP and RhoA [26].
Positive_regulation (increases) of Phosphorylation (phosphorylation) of RhoA associated with long-term potentiation
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.22 Pain Relevance 0.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox