INT317019

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.47
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tmub1) cytoplasm (Tmub1)
Tmub1 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 138 99.32 Very High Very High Very High
Thalamus 30 91.12 High High
gABA 12 29.28 Quite Low
Glutamate 6 19.04 Low Low
Buprenorphine 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
analgesia 6 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 66 81.92 Quite High
Attention Deficit Hyperactivity Disorder 6 55.88 Quite High
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Fever 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They observed an interaction of Tmub1 and GRIP in HEK293 cells, but not in a yeast two-hybrid assay.
Tmub1 Neg (not) Binding (interaction) of
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889838 Disease Relevance 0.05 Pain Relevance 0.13
Taken together our results implicate Tmub1 in the regulation of locomotor activity and wakefulness and suggest that Tmub1 binds to and functions together with CAMLG.



Tmub1 Binding (binds) of associated with eae
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2889838 Disease Relevance 0.07 Pain Relevance 0.14
The authors suggested that this process may be mediated by the interaction of GRIP and Tmub1/HOPS.
Tmub1 Binding (interaction) of
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889838 Disease Relevance 0.06 Pain Relevance 0.14
It is possible that the interaction of Tmub1 with GluR2-GRIP is indirect and requires another mediator.
Tmub1 Binding (interaction) of
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889838 Disease Relevance 0.05 Pain Relevance 0.10
The interaction of Tmub1 and CAMLG was confirmed by co-immunoprecipitation assays in HEK cells.
Tmub1 Binding (interaction) of
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2889838 Disease Relevance 0.19 Pain Relevance 0.18
The authors suggested that this process may be mediated by the interaction of GRIP and Tmub1/HOPS.
HOPS Binding (interaction) of
6) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889838 Disease Relevance 0.06 Pain Relevance 0.14

General Comments

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