INT317020

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Context Info
Confidence 0.76
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.73
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tmub1) cytoplasm (Tmub1)
Anatomy Link Frequency
liver 2
brain 1
thalamus 1
cortex 1
nervous system 1
Tmub1 (Mus musculus)
Pain Link Frequency Relevance Heat
Thalamus 45 99.68 Very High Very High Very High
Eae 207 91.00 High High
Hippocampus 9 84.24 Quite High
gABA 18 5.00 Very Low Very Low Very Low
Buprenorphine 9 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
analgesia 9 5.00 Very Low Very Low Very Low
Glutamate receptor 9 5.00 Very Low Very Low Very Low
Glutamate 9 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 99 96.64 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 9 81.28 Quite High
Anxiety Disorder 18 15.84 Low Low
Depression 9 10.40 Low Low
Sprains And Strains 18 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low
Fever 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As Tmub1 is strongly expressed in the thalamus, a structure known to play roles in arousal and the expression of sleep and wakefulness [18], we suggest the behavioral phenotype is a result of altered neuronal activity in thalamus [19], [20].
Gene_expression (expressed) of Tmub1 in thalamus associated with thalamus
1) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889838 Disease Relevance 0.08 Pain Relevance 0.27
The expression of Tmub1 is reported to be high in the brain and the protein product is found in all parts of brain examined by western blot [14].
Gene_expression (expression) of Tmub1 in brain
2) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889838 Disease Relevance 0 Pain Relevance 0.16
The cerebellum, another area where Tmub1 is highly expressed, is not known for generation of sleep rhythms; however correlations between cerebellar gene expression with sleep and wakefulness have been reported [21].
Gene_expression (expressed) of Tmub1 in cerebellum
3) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889838 Disease Relevance 0.07 Pain Relevance 0.20
Tmub1 is highly expressed in the nervous system.
Gene_expression (expressed) of Tmub1 in nervous system
4) Confidence 0.76 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2889838 Disease Relevance 0.17 Pain Relevance 0.10
Using lacZ as a reporter we found Tmub1 expression prominent in a few brain structures including the thalamus, a region known to drive wakefulness and arousal via its projections to the cortex.
Gene_expression (expression) of Tmub1 in cortex associated with thalamus
5) Confidence 0.76 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2889838 Disease Relevance 0.22 Pain Relevance 0.21
To study its physiological function, we generated mice with Tmub1 deleted by homologous recombination.
Gene_expression (generated) of Tmub1
6) Confidence 0.59 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2889838 Disease Relevance 0.19 Pain Relevance 0.11
Tmub1/HOPS was also found overexpressed during liver regeneration [1] and is an essential constituent of centrosome assembly during cell cycles in culture [15].
Gene_expression (overexpressed) of Tmub1 in liver
7) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889838 Disease Relevance 0 Pain Relevance 0
The cDNA's encoding His-tagged Tmub1 and FLAG-tagged CAMLG were expressed in HEK293 (Figure 4A, B); co-immunoprecipitation experiments confirmed their interaction in these mammalian cells (Figure 4C).
Gene_expression (expressed) of Tmub1
8) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889838 Disease Relevance 0 Pain Relevance 0.03
Tmub1/HOPS was also found overexpressed during liver regeneration [1] and is an essential constituent of centrosome assembly during cell cycles in culture [15].
Gene_expression (overexpressed) of HOPS in liver
9) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889838 Disease Relevance 0 Pain Relevance 0

General Comments

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