INT31705

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.22
First Reported 1983
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.43
Pain Relevance 6.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fads1) oxidoreductase activity (Fads1) aging (Fads1)
endoplasmic reticulum (Fads1) nucleus (Fads1) response to stress (Fads1)
Anatomy Link Frequency
hepatocytes 5
ileum 2
liver 1
neurons 1
brains 1
Fads1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 19 100.00 Very High Very High Very High
Kappa opioid receptor 2 99.90 Very High Very High Very High
qutenza 63 99.82 Very High Very High Very High
Opioid 3 99.24 Very High Very High Very High
depression 72 97.68 Very High Very High Very High
medulla 6 97.56 Very High Very High Very High
lidocaine 1 90.48 High High
opioid receptor 2 86.56 High High
narcan 2 74.08 Quite High
opiate 1 66.80 Quite High
Disease Link Frequency Relevance Heat
Depression 57 97.68 Very High Very High Very High
Suicidal Behaviour 10 95.92 Very High Very High Very High
Neuroblastoma 2 95.00 High High
Glioma 2 94.44 High High
Obesity 1 85.20 High High
Post-partum Depression 30 62.68 Quite High
Photophobia 1 51.84 Quite High
Headache 1 45.48 Quite Low
Ocular Injury 1 44.68 Quite Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of FADS1 and several other genes involved in lipid metabolism was also decreased in individuals who completed suicide [86]; however, no alterations in any of the n-3 PUFAs were found in postmortem brains from suicide completers, even in those individuals with a diagnosis of major depression [87, 88].


Gene_expression (Expression) of FADS1 in brains associated with suicidal behaviour and depression
1) Confidence 0.22 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 1.00 Pain Relevance 0.29
The mRNA expressions of delta6 and delta5 desaturases were detected by real time quantitative RT-PCR.
Gene_expression (expressions) of delta5
2) Confidence 0.08 Published 2003 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 14974737 Disease Relevance 0 Pain Relevance 0.65
Sesamin specifically inhibits delta5 desaturase activity in the Mortierella alpina fungus and rat liver microsomes, however, the effects of sesamin and capsaicin on mRNA expressions of delta6 and delta5 desaturases are not still clear.
Gene_expression (expressions) of delta5 in liver associated with qutenza
3) Confidence 0.08 Published 2003 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 14974737 Disease Relevance 0 Pain Relevance 0.42
Sesamin and capsaicin had no effect on the mRNA expressions of delta6 and delta5 desaturases in rat hepatocytes.
Gene_expression (expressions) of delta5 in hepatocytes associated with qutenza
4) Confidence 0.08 Published 2003 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 14974737 Disease Relevance 0 Pain Relevance 0.63
To measure the mRNA expressions of delta6 and delta5 desaturase, hepatocytes were cultured in the presence of sesamin or capsaicin for 24 h.
Gene_expression (expressions) of delta5 in hepatocytes associated with qutenza
5) Confidence 0.08 Published 2003 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 14974737 Disease Relevance 0 Pain Relevance 0.62
Effects of sesamin and capsaicin on the mRNA expressions of delta6 and delta5 desaturases in rat primary cultured hepatocytes.
Gene_expression (expressions) of delta5 in hepatocytes associated with qutenza
6) Confidence 0.08 Published 2003 Journal J. Nutr. Sci. Vitaminol. Section Title Doc Link 14974737 Disease Relevance 0 Pain Relevance 0.64
In this study, we investigated the effects of sesamin and capsaicin on the desaturation indexes of delta6 [(gamma-linolenic acid+dihomo-gamma-linolenic acid)/linolenic acid, (GLA+DGLA)/LA] and delta5 (arachidonic acid/DGLA, AA/DGLA) and mRNA expressions of delta6 and delta5 desaturases in rat primary cultured hepatocytes.
Gene_expression (expressions) of delta5 in hepatocytes associated with qutenza
7) Confidence 0.08 Published 2003 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 14974737 Disease Relevance 0 Pain Relevance 0.55
In this study, we investigated the effects of sesamin and capsaicin on the desaturation indexes of delta6 [(gamma-linolenic acid+dihomo-gamma-linolenic acid)/linolenic acid, (GLA+DGLA)/LA] and delta5 (arachidonic acid/DGLA, AA/DGLA) and mRNA expressions of delta6 and delta5 desaturases in rat primary cultured hepatocytes.
Gene_expression (expressions) of delta5 in hepatocytes associated with qutenza
8) Confidence 0.07 Published 2003 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 14974737 Disease Relevance 0 Pain Relevance 0.55
The selectivity index of various opioid alkaloids and peptides in binding to the mu, delta, or kappa opioid receptors was expressed as the ratio of their EC50 values in displacing two selective radiolabeled ligands: [3H]sufentanil/[3H](D-Pen2,D-Pen5)enkephalin (selectivity: mu/delta), [3H]sufentanil/[3H]U69,593 (selectivity: mu/kappa), or [3H][D-Pen2,D-Pen5]enkephalin/[3H]U69,593 (selectivity: delta/kappa).
Gene_expression (expressed) of D-Pen5 associated with kappa opioid receptor, enkephalin and opioid
9) Confidence 0.03 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2898375 Disease Relevance 0 Pain Relevance 0.68
Fos-LI produced at the dPa5 and NTS, coupled with norepinephrine-induced inhibition, was consistent with the hypothesis that light-evoked activation of trigeminal brainstem neurons involves an intraocular neurovascular mechanism with little contribution from neurons that supply the ocular surface.
Gene_expression (produced) of dPa5 in neurons associated with medulla
10) Confidence 0.01 Published 2009 Journal Neuroscience Section Abstract Doc Link 19285114 Disease Relevance 0.05 Pain Relevance 0.36
The cyclic, penicillamine(beta, beta dimethylcysteine)-containing enkephalin analogs, [D-Cys2, L-Pen5]-and [D-Cys2, D-Pen5]enkephalin and the corresponding bis-penicillamine analogs, [D-Pen2, L-Pen5]-and [D-Pen2, D-Pen5]enkephalin were synthesized and evaluated for opioid activity in the guinea pig ileum (GPI) and mouse vas deferens (MVD) bioassays and in rat brain and neuroblastoma-glioma cell membrane binding assays.
Gene_expression (synthesized) of D-Pen5 in ileum associated with neuroblastoma, enkephalin, opioid and glioma
11) Confidence 0.01 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319901 Disease Relevance 0.19 Pain Relevance 0.64
The cyclic, penicillamine(beta, beta dimethylcysteine)-containing enkephalin analogs, [D-Cys2, L-Pen5]-and [D-Cys2, D-Pen5]enkephalin and the corresponding bis-penicillamine analogs, [D-Pen2, L-Pen5]-and [D-Pen2, D-Pen5]enkephalin were synthesized and evaluated for opioid activity in the guinea pig ileum (GPI) and mouse vas deferens (MVD) bioassays and in rat brain and neuroblastoma-glioma cell membrane binding assays.
Gene_expression (synthesized) of D-Pen5 in ileum associated with neuroblastoma, enkephalin, opioid and glioma
12) Confidence 0.00 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319901 Disease Relevance 0.19 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox