INT317078

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.58
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCNN1G)
Anatomy Link Frequency
lung 1
oocytes 1
SCNN1G (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 10 97.84 Very High Very High Very High
Calcium channel 15 74.72 Quite High
depression 15 62.56 Quite High
fibrosis 5 61.36 Quite High
dexamethasone 5 40.00 Quite Low
TRP channel 5 23.52 Low Low
agonist 5 17.88 Low Low
imagery 10 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 20 97.92 Very High Very High Very High
Coronary Artery Disease 5 96.52 Very High Very High Very High
Pressure And Volume Under Development 45 96.48 Very High Very High Very High
Targeted Disruption 10 71.44 Quite High
Depression 15 62.56 Quite High
Cystic Fibrosis 5 61.36 Quite High
Lung Injury 5 11.12 Low Low
Overdose 5 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To measure the regulation of ENaC-associated transepithelial Isc levels by representative examples from the other three subgroups of CCB compounds, confluent H441 monolayers were exposed to nifedipine, bepridil, and diltiazem (Fig. 3).
Regulation (regulation) of ENaC
1) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0 Pain Relevance 0.03
If the K+ channel openers restore the depressed ENaC and Na+/K+-ATPase by stimulating K+ influx which facilitates Na+/K+-ATPase in intact cells, no effects on ENaC should be observed in basolateral permeabilized monolayers.
Neg (no) Regulation (effects) of ENaC
2) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.07 Pain Relevance 0
We hence speculated that verapamil might indirectly influence ENaC activity by altering K+ channels.
Spec (might) Regulation (influence) of ENaC
3) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0 Pain Relevance 0
Lung epithelial Na+ channels (ENaC) are regulated by cell Ca2+ signal, which may contribute to calcium antagonist-induced noncardiogenic lung edema.
Regulation (regulated) of ENaC in lung associated with pressure and volume under development and antagonist
4) Confidence 0.02 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2889873 Disease Relevance 0.16 Pain Relevance 0.12
In this study, we investigated the effects of verapamil on ENaC activity in confluent H441 monolayers-a human bronchoalveolar epithelial cell line, in Xenopus oocytes heterologously expressing human ???
Spec (investigated) Regulation (effects) of ENaC in oocytes
5) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.35 Pain Relevance 0.03

General Comments

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