INT317117

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Context Info
Confidence 0.77
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 45
Disease Relevance 13.85
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ncs1) Golgi apparatus (Ncs1) plasma membrane (Ncs1)
cytoplasm (Ncs1)
Anatomy Link Frequency
neurons 12
spinal cord 4
neurite 4
neuronal 2
midline 2
Ncs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 1350 99.16 Very High Very High Very High
agonist 45 88.56 High High
Central nervous system 180 86.48 High High
lumbar region 45 81.60 Quite High
medulla 270 80.96 Quite High
anesthesia 45 80.64 Quite High
Peripheral nervous system 45 67.76 Quite High
dorsal root ganglion 45 63.52 Quite High
imagery 45 12.16 Low Low
ketamine 45 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1710 100.00 Very High Very High Very High
Injury 1080 99.98 Very High Very High Very High
Cytomegalovirus Infection 315 99.40 Very High Very High Very High
Frailty 225 98.44 Very High Very High Very High
Keloid Scars 45 92.52 High High
Death 45 89.36 High High
Body Weight 45 82.16 Quite High
Pheochromocytoma 45 70.96 Quite High
Ganglion Cysts 45 62.56 Quite High
Nervous System Injury 45 29.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the demonstration that NCS1 overexpression induces neurite sprouting in primary cultured adult cortical neurons, it was next determined whether this also occurred in vivo.
Gene_expression (overexpression) of NCS1 in neurons
1) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.32 Pain Relevance 0
In injured corticospinal neurons, overexpression of NCS1 induced axonal sprouting and regeneration and also neuroprotection.
Gene_expression (overexpression) of NCS1 in neurons
2) Confidence 0.77 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2889931 Disease Relevance 0.28 Pain Relevance 0.19
In primary cultured adult cortical neurons, the lentivector-induced overexpression of NCS1 induces neurite sprouting associated with increased phospho-Akt levels.
Gene_expression (overexpression) of NCS1 in neurite
3) Confidence 0.77 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2889931 Disease Relevance 0.24 Pain Relevance 0.08
These data show that GFP allows a precise identification both of co-labelled transduced neurons overexpressing NCS1 and of their axons, thus obviating the need for later labelling with neuronal tracers or by the use of an independent virus expressing LacZ or GFP.


Gene_expression (overexpressing) of NCS1 in neuronal
4) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.35 Pain Relevance 0.03
The overexpression of NCS1 in uninjured corticospinal neurons exhibited axonal sprouting across the midline into the CST-denervated side of the spinal cord following unilateral pyramidotomy.
Gene_expression (overexpression) of NCS1 in midline associated with spinal cord
5) Confidence 0.77 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2889931 Disease Relevance 0.28 Pain Relevance 0.11
To demonstrate further that overexpressed NCS1 had induced axon collateral sprouting from the intact CST, extending into the CST-denervated side of the spinal cord, a subsequent lesion of the intact pyramidal tract (termed second lesion) was made at medullary level (Figures S4A and S5E–S5H).
Gene_expression (overexpressed) of NCS1 in spinal cord associated with spinal cord
6) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.21 Pain Relevance 0.07
In this study, NCS1 overexpression has been demonstrated in axotomized CSN to induce axonal sprouting and regeneration.
Gene_expression (overexpression) of NCS1
7) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0 Pain Relevance 0.14
Conversely, in the present study, NCS1 overexpression induces sprouting from both axons and dendrites in cultured neurons, suggesting the growth induction process of NCS1 is non-selective.
Gene_expression (overexpression) of NCS1 in neurons
8) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.14 Pain Relevance 0.11
In culture, neurons overexpressing NCS1 develop extensive neurite sprouting which by immunocytochemistry and Western blotting was shown to be via Akt phosphorylation.
Gene_expression (overexpressing) of NCS1 in neurite
9) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.16 Pain Relevance 0.04
These data show that overexpression of NCS1 in CSN at the cortical level can induce distal axon collateral sprouting across the midline into the CST-denervated side of the cervical and lumbar spinal cord.


Gene_expression (overexpression) of NCS1 in spinal cord associated with spinal cord
10) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.22 Pain Relevance 0.10
Furthermore, studies on the axotomized CSN show that NCS1 overexpression not only induces axonal sprouting and regeneration at the lesion site but also exerts a neuroprotective affect on injured CSN.
Gene_expression (overexpression) of NCS1
11) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.09 Pain Relevance 0.13
To allow for coexpression of NCS1 and the enhanced green fluorescent protein (GFP), the eGFP gene was inserted into the Cla1 site under the control of a SFFV promoter.
Gene_expression (coexpression) of NCS1
12) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.69 Pain Relevance 0.04
This demonstrates that the reduction in phospho-Akt level was a direct result of LY249002 and not via the NCS1 overexpression itself.
Gene_expression (overexpression) of NCS1
13) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.29 Pain Relevance 0
These data show that delaying the overexpression of NCS1 in CSN after injury can still induce intact CST axons to sprout into the CST-denervated side of the spinal cord.


Gene_expression (overexpression) of NCS1 in spinal cord associated with injury and spinal cord
14) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.50 Pain Relevance 0.14
The type of neurite that has undergone sprouting with NCS1 overexpression was further investigated using the specific dendritic immunomarker microtubule-associated protein 2 (MAP2).
Gene_expression (overexpression) of NCS1 in neurite
15) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.51 Pain Relevance 0
Similarly, analogous experiments conducted in vivo show that CSN overexpressing NCS1 with intact CST axons can undergo distal collateral sprouting and cross the midline into the CST-denervated side of the spinal cord.
Gene_expression (overexpressing) of NCS1 in midline associated with spinal cord
16) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.06 Pain Relevance 0.08
High efficiency was achieved of both GFP and NCS1 expression in the CSN at 3 wk with HIV-GFP-NCS1 (Figure 5A–5C).
Gene_expression (expression) of NCS1 associated with acquired immune deficiency syndrome or hiv infection
17) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.35 Pain Relevance 0
These data indicate the levels of phospho-Akt are elevated in neurons with overexpressed NCS1 and blockade of Akt production reduces neurite sprouting in these neurons.
Gene_expression (overexpressed) of NCS1 in neurite
18) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.09 Pain Relevance 0
These data show that overexpression of NCS1 in CSN at the cortical level can induce intact CST to form functional connections in the CST-denervated side of the spinal cord.


Gene_expression (overexpression) of NCS1 in spinal cord associated with spinal cord
19) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.07 Pain Relevance 0.09
The HIV-GFP-NCS1 lentivector injected into the cortex enabled GFP labelling of neurons overexpressing NCS1.
Gene_expression (overexpressing) of NCS1 in neurons associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.77 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.15 Pain Relevance 0.13

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