INT317124

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 36
Disease Relevance 10.64
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ncs1) Golgi apparatus (Ncs1) plasma membrane (Ncs1)
cytoplasm (Ncs1)
Anatomy Link Frequency
neurons 22
neurite 10
spinal cord 8
midline 4
decussation 2
Ncs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 1080 99.16 Very High Very High Very High
agonist 36 88.56 High High
Central nervous system 144 86.48 High High
lumbar region 36 81.60 Quite High
Peripheral nervous system 36 67.76 Quite High
dorsal root ganglion 36 63.52 Quite High
medulla 216 5.00 Very Low Very Low Very Low
ketamine 36 5.00 Very Low Very Low Very Low
anesthesia 36 5.00 Very Low Very Low Very Low
imagery 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1368 100.00 Very High Very High Very High
Injury 864 99.98 Very High Very High Very High
Cytomegalovirus Infection 252 99.04 Very High Very High Very High
Frailty 180 98.44 Very High Very High Very High
Keloid Scars 36 92.52 High High
Death 36 89.36 High High
Pheochromocytoma 36 70.96 Quite High
Ganglion Cysts 36 62.56 Quite High
Nervous System Injury 36 29.36 Quite Low
Camurati-engelmann Disease 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, in the present study, NCS1 overexpression induces sprouting from both axons and dendrites in cultured neurons, suggesting the growth induction process of NCS1 is non-selective.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1 in neurons
1) Confidence 0.69 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.14 Pain Relevance 0.11
These data show that GFP allows a precise identification both of co-labelled transduced neurons overexpressing NCS1 and of their axons, thus obviating the need for later labelling with neuronal tracers or by the use of an independent virus expressing LacZ or GFP.


Positive_regulation (overexpressing) of Gene_expression (overexpressing) of NCS1 in neuronal
2) Confidence 0.69 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.35 Pain Relevance 0.03
The overexpression of NCS1 in uninjured corticospinal neurons exhibited axonal sprouting across the midline into the CST-denervated side of the spinal cord following unilateral pyramidotomy.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1 in midline associated with spinal cord
3) Confidence 0.69 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2889931 Disease Relevance 0.28 Pain Relevance 0.11
In culture, neurons overexpressing NCS1 develop extensive neurite sprouting which by immunocytochemistry and Western blotting was shown to be via Akt phosphorylation.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of NCS1 in neurite
4) Confidence 0.69 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.16 Pain Relevance 0.04
With the demonstration that NCS1 overexpression induces neurite sprouting in primary cultured adult cortical neurons, it was next determined whether this also occurred in vivo.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1 in neurons
5) Confidence 0.69 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.32 Pain Relevance 0
Furthermore, studies on the axotomized CSN show that NCS1 overexpression not only induces axonal sprouting and regeneration at the lesion site but also exerts a neuroprotective affect on injured CSN.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1
6) Confidence 0.69 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.09 Pain Relevance 0.13
To demonstrate further that overexpressed NCS1 had induced axon collateral sprouting from the intact CST, extending into the CST-denervated side of the spinal cord, a subsequent lesion of the intact pyramidal tract (termed second lesion) was made at medullary level (Figures S4A and S5E–S5H).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of NCS1 in spinal cord associated with spinal cord
7) Confidence 0.69 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.21 Pain Relevance 0.07
In primary cultured adult cortical neurons, the lentivector-induced overexpression of NCS1 induces neurite sprouting associated with increased phospho-Akt levels.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1 in neurite
8) Confidence 0.69 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2889931 Disease Relevance 0.24 Pain Relevance 0.08
In injured corticospinal neurons, overexpression of NCS1 induced axonal sprouting and regeneration and also neuroprotection.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1 in neurons
9) Confidence 0.69 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2889931 Disease Relevance 0.28 Pain Relevance 0.19
These data show that delaying the overexpression of NCS1 in CSN after injury can still induce intact CST axons to sprout into the CST-denervated side of the spinal cord.


Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1 in spinal cord associated with injury and spinal cord
10) Confidence 0.69 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.50 Pain Relevance 0.14
This demonstrates that the reduction in phospho-Akt level was a direct result of LY249002 and not via the NCS1 overexpression itself.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1
11) Confidence 0.69 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.29 Pain Relevance 0
These data indicate the levels of phospho-Akt are elevated in neurons with overexpressed NCS1 and blockade of Akt production reduces neurite sprouting in these neurons.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of NCS1 in neurite
12) Confidence 0.69 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.09 Pain Relevance 0
The HIV-GFP-NCS1 lentivector injected into the cortex enabled GFP labelling of neurons overexpressing NCS1.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of NCS1 in neurons associated with acquired immune deficiency syndrome or hiv infection
13) Confidence 0.69 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.15 Pain Relevance 0.13
To investigate whether a delayed NCS1 overexpression in CSN can also promote axon collateral sprouting to the same extent as priming the CSN for 3 wk, adult Wistar rats received unilateral intracortical injections of either HIV-GFP-NCS1 or the control HIV-GFP lentivector 2 d after receiving on the contralateral side a unilateral pyramidal tract lesion (Figure S4B).
Spec (whether) Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1 associated with acquired immune deficiency syndrome or hiv infection
14) Confidence 0.69 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.31 Pain Relevance 0.03
The successful regenerative responses of CSN after pyramidotomy with delayed post-injury NCS1 overexpression suggests axonal sprouting and regeneration can occur without the need to prime with overexpression of NCS1.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1 associated with injury
15) Confidence 0.50 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.46 Pain Relevance 0.09
In injured corticospinal neurons, overexpression of NCS1 induced axonal sprouting and regeneration and also neuroprotection.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1 in neurons
16) Confidence 0.50 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2889931 Disease Relevance 0.28 Pain Relevance 0.19
The type of neurite that has undergone sprouting with NCS1 overexpression was further investigated using the specific dendritic immunomarker microtubule-associated protein 2 (MAP2).
Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1 in neurite
17) Confidence 0.50 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.51 Pain Relevance 0
These data indicate that primary cultured adult cortical neurons overexpressed with NCS1 have significantly more neurites and sprouts from dendrites and axons than the control neurons.


Positive_regulation (overexpressed) of Gene_expression (overexpressed) of NCS1 in neurons
18) Confidence 0.50 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.24 Pain Relevance 0
In primary cultured adult cortical neurons, the lentivector-induced overexpression of NCS1 induces neurite sprouting associated with increased phospho-Akt levels.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1 in neurite
19) Confidence 0.50 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2889931 Disease Relevance 0.24 Pain Relevance 0.08
To investigate whether a delayed NCS1 overexpression of axotomized CSN can promote axonal sprouting and regeneration, adult Wistar rats received unilateral intracortical injections of either HIV-GFP-NCS1 or the control HIV-GFP lentivector 2 d after receiving on the ipsilateral side a unilateral pyramidal tract lesion at the medullary level, approximately 2 mm rostral to the decussation (Figures S4C and 5A–5B).
Spec (whether) Positive_regulation (overexpression) of Gene_expression (overexpression) of NCS1 in decussation associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.50 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.53 Pain Relevance 0.13

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